Sickle cell disease (SCD) results from a single base pair change in the β-globin subunit, yet the downstream effects and complex manifestations that result are protean and variable. The abnormal HbS is insoluble when deoxygenated and polymerizes causing deformation of…
Immune thrombocytopenia (ITP) is a bleeding disorder characterized by immune-mediated platelet destruction and resultant thrombocytopenia. Two forms of ITP had been described previously: acute ITP that resolves within 6 months and chronic ITP that persists beyond 6 months. Recently, an…
Basic Considerations for Evaluation of a Pediatric Patient With a Bleeding Disorder Children with bleeding disorders generally present with mild bleeding symptoms including easy bruising, epistaxis, gum bleeding, abnormal clotting tests from presurgical evaluation, or known family history of bleeding…