Key points After reading this chapter, readers will be familiar with the epidemiology of congenital infections such as CMV, HSV, Zika, and SARS-CoV-2 virus. Risk factors for acquiring these infections are discussed. Clinical manifestations, diagnosis, treatment, and clinical outcomes are…
In 1963, idoxuridine became the first antiviral compound to be licensed by the US Food and Drug Administration (FDA) for the topical treatment of herpes simplex virus (HSV) keratitis. This was followed shortly by licensure of amantadine in 1966 as…
Herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) belong to the Alphaherpesvirinae subfamily of herpesviruses. The large DNA viruses have a short reproductive cycle, rapidly produce lytic infection in tissue culture, and remain latent in sensory neural ganglia.…
The family Herpesviridae contains three subfamilies: Alphaherpesvirinae, Betaherpesvirinae, and Gammaherpesvirinae. , The eight known human herpesviruses are represented in six genera, which are shown with the typical characteristics of the subfamilies in Table 203.1 . TABLE 203.1 Members of Herpesviridae…
Neonatal herpes simplex virus infection (HSV) was identified as a distinct disease in the 1930s. The first written descriptions of neonatal HSV were attributed to Hass, who described the histopathologic findings of a fatal case, and to Batignani, who described…