The myelodysplastic syndromes (MDS) include a group of clonal hematopoietic disorders characterized by ineffective hematopoiesis and blood cytopenias, abnormal blood and bone marrow cell morphology ( Fig. 61.1 ), and a risk of clonal evolution including progression to acute myeloid…
The myelodysplastic syndromes (MDS) include a group of clonal hematopoietic disorders characterized by ineffective hematopoiesis and blood cytopenias, abnormal blood and bone marrow cell morphology ( Fig. 61.1 ), and a risk of clonal evolution including progression to acute myeloid…
Summary of Key Points Etiology The myelodysplastic syndromes (MDS) are a group of clonal marrow failure syndromes originating in a hematopoietic progenitor or stem cell. Approximately 25% to 30% of MDS cases eventually progress to acute myeloid leukemia (AML), which…