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Introduction The formation and subsequent development of the heart is a complex process that involves multiple cell populations, a plethora of molecular regulatory mechanisms, and intrinsic, complicated spatiotemporal remodeling events. When all the developmental steps have been properly concluded, the…
Origins of Cardiac Precursor Populations Heart development begins as the primary germ layers—ectoderm, mesoderm, and endoderm—are induced and progressively changed to various cell types during the morphogenetic process of gastrulation. Combinatorial networks of intercellular signaling events cooperate with massive tissue…