Surgical Management of Femoral, Popliteal, and Tibial Arterial Occlusive Disease

Toe and Foot Amputations, Debridements, and Conservative Treatment

Although a detailed description of these procedures is beyond the scope of this chapter, certain principles should be emphasized. Gangrenous and infected toes can be successfully amputated by closed or open techniques in patients with good circulation, manifested by pedal pulses. Extensive debriding and partial foot amputations will usually heal in patients if all infected and necrotic tissue is excised. Such procedures will result in patients regaining effective walking. Amputation of one or more gangrenous or ulcerated toes or limited debriding may also result in a healed foot in patients without distal pulses and substantial arterial occlusive disease (e.g., an occluded superficial femoral artery [SFA]). Determination of moderately good collateral circulation by ankle-brachial indices or pulse volume recordings may be helpful in predicting healing; however, sometimes in patients with borderline circulation, a trial at local procedures is warranted before proceeding with a major effort at revascularization. If prompt healing does not occur, revascularization is justified and should be performed without delay.

Some patients with critical ischemia, manifested by mild ischemic rest pain or limited gangrene or ulceration, can be treated conservatively with good foot care, antibiotics, analgesics, and limited ambulation. Conservative treatment is indicated in patients who might not tolerate revascularization procedures because of major comorbidities. Long periods of palliation and occasional healing of small ulcerations or gangrenous patches may occur in a few patients with critical ischemia.

History of Aggressive Approach to Limb Salvage

In the 1960s and 1970s, major below-knee or above-knee amputation was regarded as the safest and best treatment for gangrene and ulceration from arteriosclerotic occlusive disease below the inguinal ligament, despite the effectiveness of reconstructive arterial surgery (bypass and endarterectomy) for aortoiliac occlusive disease and despite some occasional positive results from femoropopliteal and even femorotibial bypasses. Because we had access to unusually good arteriography that visualized all the arteries in the leg and foot ( Fig. 28.1 ), we developed and promoted an aggressive approach to salvage threatened limbs, including those with extensive gangrene. More than 96% of patients with threatened limbs were subjected to an effort to save the limb. Only 4%, those with severe dementia or gangrene extending beyond the midfoot, were excluded. Only 6% of all patients with threatened limbs, when examined by arteriography, had no patent artery in the leg or foot that could serve as an outflow site for a bypass. With improvements in technique, this proportion of patients with arteries unsuitable for a bypass fell to 1% to 2%. Successful foot salvage was achieved in 81% to 95% of patients in whom bypasses were performed for the period that they lived, up to 5 years. However, 52% of these limb salvage patients had medical comorbidities and died, usually from cardiac causes, within the first 5 years after their initial bypass. More than two-thirds of the patients who lived beyond 5 years retained a useable limb and were able to ambulate beyond the 5-year time point. However, to maintain limb salvage, many of these patients required reoperation or reintervention because they developed a failed (thrombosed) or failing (threatened but patent) graft from a lesion in their graft or its inflow or outflow tract. These limb salvage results were achieved because of a myriad of improvements in the surgical techniques, developed to facilitate the reoperations these patients required, and because of improved anesthetic and intensive care management of limb-salvage patients who often had advanced cardiorespiratory disease, poor kidney function, and diabetes. Collectively, these improvements made it possible to attempt limb salvage in almost every patient with a threatened limb and intact brain function. Many vascular centers throughout the world adopted these policies and were able to achieve equally good results.

Early Use of Endovascular Techniques With Bypass Surgery

In the mid-1970s, some centers embraced the use of percutaneous transluminal angioplasty (PTA) to treat elderly patients with critical limb ischemia. Initially, PTA was used to correct hemodynamically significant iliac artery stenosis. In most instances, it was combined with some form of infrainguinal bypass. However, as PTA techniques improved, balloon angioplasty was used to treat short iliac occlusions and some SFA lesions. Approximately 20% of patients with a threatened limb could be treated with PTA alone without an adjunctive bypass, whereas another 14% required some form of open surgical revascularization along with their PTA. These percentages increased and results improved with the introduction of iliac stents. As technical improvements in endovascular technology were developed, it became possible to use popliteal, infrapopliteal, and tibial PTA to treat some of these limb salvage patients less invasively and to avoid some of the systemic and local complications of the lengthy and sometimes difficult distal operations in these high-risk elderly patients. These endovascular techniques could also be used to treat patients with failed or failing bypasses, because reoperative procedures are often more difficult than primary bypass operations. Sometimes (in approximately 20% of patients) PTA eliminated the need for a secondary bypass: more often it made the secondary bypass simpler. In addition, we developed a number of unusual approaches to lower extremity arteries to facilitate reoperations by eliminating the need to redissect previously dissected arteries.

Current and Future Relationship Between Endovascular Treatments and Open Bypass Surgery

Recent improvements in catheter, guidewire, stent, and stent-graft technology have transformed the treatment of lower limb ischemia from a primarily open surgical modality, supplemented by catheter-based treatments, to a primarily endovascular modality supplemented by surgery. Most who treat critical ischemia regard endovascular treatments as the first option to treat chronic obstructive arteriosclerosis at all levels, including disease in the leg and foot. Indeed, there are some endovascular enthusiasts who mistakenly believe they have originated the limb salvage concept, and some maintain that if a limb cannot be salvaged by endovascular treatment, the next option should be a major amputation.

Although endovascular treatment should be the first therapeutic option to revascularize a critically ischemic limb in most patients, some patients whose leg and foot cannot be saved by endovascular treatment can undergo an open surgical bypass procedure to salvage a foot.

Although there are still some indications for open surgical bypasses for limb-threatening ischemia, there is wide variation in opinions about the proportion of patients with critical ischemia that require an open bypass at some point in their disease process. We believe that at least 20% to 35% of patients with critical ischemia will require open surgery at some point in the course of their disease, although endovascular techniques continue to improve, so that this proportion may decrease in the future. We also believe that such procedures will usually be indicated after failures of one, or usually more, endovascular treatments, although there are some patients with extensive foot gangrene, long occlusions, limited target outflow arteries, and a good greater saphenous vein in whom a bypass is the best initial treatment option. The initial surgical option depends on many factors, such as the age and health of the patient, the pattern of disease, and the skills of the involved interventionalist and surgeon. One real concern is that, as fewer bypasses are performed, fewer surgeons will be skilled in these demanding bypass techniques, particularly in the difficult circumstances in which they will be needed. Perhaps referral centers for bypasses should be established for the same reasons that such centers have been recommended for patients who require open thoracoabdominal aneurysm repair.

It has been recognized for many years that repetitive or redo procedures are an important component of care for patients with critical ischemia. Endovascular procedures may be used to salvage limbs after failed or failing open surgical bypasses, and this tendency will increase as technology improves. Similarly, bypass operations or partially open thrombectomy will be required after early or late failure of endovascular procedures or prior bypasses in patients in whom no further endovascular options are available. Most of the 20% to 35% of critical ischemia patients who require an open surgical bypass or thrombectomy will require it in such a setting.

There are certain principles and precautions that should be followed by those performing endovascular interventions for limb ischemia. These interventions should be performed in a way that preserves at least one good target outflow artery, leaving the option of an open surgical rescue if the intervention fails. In addition, care must be taken not to render initially patent arterial segments unusable, thereby necessitating a more distal bypass than would have been required before the endovascular procedure. Moreover, key collateral vessels should be preserved so that the patient will not be worse than he originally was if the intervention fails.