Signet-Ring Cell Carcinoma of the Cervix


D efinition A rare variant of invasive adenocarcinoma originating in the endocervix.

Clinical Features

Epidemiology

  • Limited to case reports.

  • Wide age range, but most present in the fourth or fifth decade.

  • Human papillomavirus (HPV) associated.

  • May be found with other adenocarcinomas such as usual type of adenocarcinoma or neuroendocrine carcinoma (rare cases).

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