Physostigmine, Eserine


Uses

  • Central anticholinergia; used for diagnosis and treatment in patients with a Hx of anticholinergic ingestion and/or exposure: Atropine, scopolamine, belladonna, jimson weed, toxic mushrooms, tricyclics, phenothiazines, antihistamines, benzodiazepines, opiates, inhalation anesthetics, propofol, GHB.

    • “Blind as a bat”: Mydriasis and loss of accommodation

    • “Dry as a bone”: Urinary retention and dry mucous membranes

    • “Hot as a hare”: Hyperthermia from loss due to sweating

    • “Red as a beet”: Cutaneous vasodilation; counteracts hyperthermia

    • “Mad as a hatter”: Fluctuating consciousness, delirium, disorientation, decreased social restraint, slurred speech, incoordination, hallucinations, phantom behaviors, coma, paranoia during recovery

  • Postop delirium from agitation to excessive somnolence. Best indication for treatment of combined central and peripheral anticholinergia.

  • Glaucoma, ciliary muscle contraction = miosis = facilitates outflow of aqueous humor.

  • Treatment for antimuscarinic xenobiotic toxicity (a chemical compound that is foreign to a living organism; e.g., benzodiazepines, tricyclics, antihistamines, jimson weed).

  • Reversal of NMB (neostigmine a better choice as it avoids CNS effects).

  • Hereditary ataxias.

  • Alzheimer disease (may improve short-term memory but not used clinically).

  • Analgesia (decreases morphine consumption postop).

Perioperative Risk

  • Cholinesterase inhibition = excess acetylcholine. Can lead to three sets of problems: Analogous to organophosphorus compound poisoning, a cholinergic crisis (basically the opposite of anticholinergia syndrome above)

    • Muscarinic cholinergic (parasympathetic) over-stimulation (DUMBELS): D = Defecation, diarrhea, diaphoresis, GI distress; U = urination; M = miosis; B = bronchorrhea, bronchospasm, bradycardia; E = emesis (nausea); L = lacrimation; S = salivation

    • Nicotinic cholinergic excess (continuing depolarization of motor endplate, leading to fasciculations at low doses and progressive weakness at high doses)

    • CNS (anxiety, confusion, tremors, seizures, respiratory depression, coma)

Worry About

  • Reactive airway disease

  • Peripheral vascular disease

  • Diabetes

  • Bowel or bladder obstruction

  • Preexisting intraventricular conduction delay, long-QT syndrome

  • Preexisting AV block

  • Pregnancy (class C)

  • Sulfite allergy (contains sodium bisulfite preservative)

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