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Nephrogenic rests and nephroblastomatosis
Definition
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Nephrogenic rests are abnormally persistent embryonal cells beyond 36 weeks of gestation and are associated with and capable of developing into nephroblastomas (Wilms tumor).
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Nephroblastomatosis is defined as the presence of diffuse and multifocal nephrogenic rests.
Clinical features
Epidemiology
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Encountered in 40% of patients with unilateral nephroblastoma and nearly 100% of patients with bilateral nephroblastomas
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Observed in 1% of infant autopsies
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