Hypertriglyceridemia

Prolonged propofol infusion due to lipid vehicle

Genetic defects in triglyceride metabolism

Component of the metabolic syndrome (obesity, hypertriglyceridemia, low HDL, Htn, diabetes)

Associated with atherosclerosis, coronary, and cerebrovascular disease.

Hyperglycemia (metabolic syndrome) increases risk of surgical wound infection.

Severe hypertriglyceridemia may cause acute pancreatitis.

Coronary and cerebrovascular disease

Pancreatitis

Blood sugar control in metabolic syndrome

Propofol infusion syndrome if hypertriglyceridemia is due to prolonged propofol infusion (hypertriglyceridemia due to propofol may occur with or without other features of propofol infusion syndrome, including rapidly progressive myocardial failure, bradycardia, ECG changes resembling Brugada syndrome, lactic acidosis, rhabdomyolysis, elevated serum creatine kinase, urea and potassium, elevated liver enzymes, hepatomegaly, and lipemic blood)

High triglycerides are strongly associated with coronary artery atherosclerosis.

Normal <150 mg/dL, borderline high 150–199 mg/dL, high 200–499 mg/dL, very high >500.

>1000 mg/dL: Severe hypertriglyceridemia may cause acute pancreatitis.

Prolonged and/or high-dose propofol infusion may produce hypertriglyceridemia.

Primary hypertriglyceridemia is caused by a variety of disorders of triglyceride metabolism.

Secondary hypertriglyceridemia is caused primarily by obesity, diabetes, nephrotic syndrome, hypothyroidism, pregnancy, restrogen replacement, tamoxifen, beta-blockers, immunosuppressive medications, HIV antiretroviral agents, and retinoids.