Extremity Causalgia: Reflex Sympathetic Dystrophy


Understanding the pathophysiology and management of extremity causalgia, a complex regional pain syndrome (CPRS), is relevant to the practice of vascular surgery. Patient referrals for extremity complaints (pain, cyanosis, skin temperature changes, edema) can mimic arterial and venous disease, but once a vascular abnormality is excluded, a neurogenic basis for the symptom complex should be considered.

Reflex sympathetic dystrophy (RSD), a type I CRPS, displays specific clinical features of burning extremity pain, sympathetic hyperactivity, muscle wasting, joint stiffness, and trophic skin changes. The condition is often underdiagnosed or misdiagnosed following trauma, with a prevalence of 2% to 5% following peripheral nerve injury, 1% to 2% after bone fracture, and less than 1% after soft tissue contusion or surgical procedures.

In 1995, the International Association for the Study of Pain recommended CRPS be classified into two types: type I or RSD, and type II, a pain syndrome with documented peripheral injury as the initiating factor. Although the CPRS classification has been adopted by pain specialists, the condition of RSD remains rooted in diagnostic terminology with patients and primary care physicians and in the determination of medical disability caused by workplace accidents. The term mimocausalgia has also been used to denote RSD symptoms occurring late after minor extremity trauma and should be considered type I CPRS, but the diagnosis of mimocausalgia can delay recognition of RSD and medical treatment owing to its uncommon usage.

The development of RSD is poorly understood, but it is related to sympathetic nerve dysfunction and involves three nervous system mechanisms ( Figure 1 ):

  • Increased afferent impulses from peripheral nerves after injury caused by increased sensitivity to norepinephrine released by sympathetic postganglionic neurons

  • Regenerating primary afferents from artificial synapses with regenerating sympathetic neurons

  • Increased stimulation in the internuncial pool located in the anterior horn of the spinal cord, with gate-opening transmission of peripheral nerve impulses to the brain resulting in increased pain perception

FIGURE 1
Mechanism of reflex sympathetic dystrophy. A, Injury to the extremity initiates a pain impulse carried by sensory nerves to the central nervous system. B, The pain impulse in turn triggers a sympathetic nervous system response that returns to the site of injury. C, The sympathetic nerves trigger an inflammatory response, causing arterial spasm, swelling, and pain. D, The pain triggers a cyclic response of increasing pain and swelling manifest as burning extremity pain and skin mottling.

The onset of RSD following extremity trauma is variable, but it typically develops within weeks of the injurious event. Initially, the extremity pain and disability may be characterized by intervals of exacerbation followed by partial remission, but the normal healing process with pain resolution does not occur. Rather, chronic sympathetic nerve dysfunction triggers an inflammatory response producing cyclic vasospasm and pain sensitivity to even the slightest touch (tactile allodynia).

The pathophysiology of RSD results in the signs of mottled skin, muscle spasms, and joint immobility, but the primary compliant is a disabling burning pain in the extremity. This CPRS condition can develop in children and adults and has no apparent no gender predisposition. Its development is associated with a variety of events, with the common denominator being extremity injury ( Box 1 ). Young (15-30 yr), active adults appear to be the most prone to RSD, which develops when extremity injury does not follow the normal path of healing. Development does not depend on the magnitude of injury, and initial diagnosis can be hampered by the lack of physical findings in the setting of severe extremity pain. Joint sprains and repetitive motion disorders, such as carpal tunnel syndrome, can produce RSD and result in accusations of malingering if the inciting event was work related.

BOX 1
Conditions Associated with Development of Reflex Sympathetic Dystrophy

  • Trauma, including musculoskeletal sprain and soft tissue contusion

  • Repetitive motion disorder: carpal tunnel or tarsal tunnel syndrome

  • Soft tissue infection

  • Osteoarthritis

  • Extremity surgery, including varicose vein procedures

  • Cervical and lumbar disk disease

  • Thrombophlebitis

  • Venipuncture, including intravenous infiltrations

There is no definitive radiologic or diagnostic test to confirm the diagnosis of RSD. Standard extremity x-rays can rule out bone disease, although chronic CPRS is associated with patch osteoporosis, which can be confirmed by a three-phase bone scan. Thermography indicates a cool affected extremity relative to the other limbs, and other signs of sympathetic hyperactivity (sweat output, skin color changes) are used to augment the clinical impression.

In 1959, Drucker and colleagues characterized three clinical stages of RSD with the progression of symptoms and disability occurring in an unpredictable manner with time ( Box 2 ). In stage I RSD, extremity pain is localized to the region of injury but with pain increasing during the healing process. Extremity tenderness and sensitivity to normal touch or motion is out of proportion to what is expected based on objective signs (contusion, fracture, surgical site healing). The pain is described as constant, with features of a burning sensation or a deep ache. Any repetitive tactile contact escalates pain severity (allodynia) and causes the pain to persist for an extended time period (hyperpathia). Palpation of skin trigger points as seen with other myofascial pain syndromes can often be elucidated on questioning the patient or performing physical examination. Evaluating the patient by sympathetic block is both diagnostic and therapeutic, because the clinical course of acute RSD may be reversible, and regional sympathetic block can provide pain relief well beyond the normal duration of the local anesthetic drug used.

BOX 2
Classification of Severity of Reflex Sympathetic Dystrophy

Stage I

  • Onset of severe burning pain limited to site of injury

  • Skin sensitivity to touch and light pressure (hyperesthesia)

  • Localized swelling

  • Muscle cramps

  • Stiffness and limited mobility

  • Skin color and temperature changes from erythema/warm to cyanosis/cold

  • Increased sweating (hyperhidrosis)

Stage II

  • Diffuse severe pain not limited to the site of injury

  • Spreading limb swelling that can change from soft to brawny

  • Muscle spasms with involuntary movement

  • Changes in hair (coarse, alopecia) and nails (slow growth, brittle, grooved)

  • Patchy bone wasting: osteoporosis

  • Muscle atrophy

Stage III

  • Intractable pain

  • Irreversible muscle atrophy

  • Joint contracture

  • Reflex sympathetic dystrophy can spread to the contralateral extremity and to other body regions

Progression of RSD to stage II is manifest by the development of visible skin changes, including cold sensitivity, cyanosis, sweating or skin dryness, muscle atrophy, and joint stiffness. Cold sensitivity is present with all RSD stages and typically is associated with manifestations of excessive sympathetic tone such as hyperhidrosis, cool skin temperature, and pilomotor changes. Abnormalities of bone structure (osteoporosis), hair growth, and nail texture (brittleness) can occur. This dystrophic stage of RSD is associated with a positive bone scan demonstrating increased calcium absorption. Limb swelling is also a common sign of RSD progression and can develop into a hard, brawny form of lymphedema, especially in the lower extremity. Muscle and joint stiffness produces decreased range of motion and may be accompanied by involuntary spasms and eventually limb disuse. Pain relief with a sympathetic block indicates a sympathetic-maintained pain syndrome, but the condition is not unlikely to spontaneously resolve without proper therapeutic intervention.

In stage III RSD, the condition is associated with extremity atrophy and intractable pain. The likelihood that pain relief occurs with sympathetic block decreases, and if a block produces no pain relief, the condition is termed sympathetic independent. The burning pain can spread beyond the affected extremity to the trunk, face, and other extremities (upper or lower). The onset of spreading RSD can occur without an identifiable traumatic event. If symptoms are associated with excessive sympathetic activity, sympathetic blocks and sympathectomy might provide pain relief to the other involved extremities.

Early diagnosis of RSD coupled with medical and rehabilitative therapy, including sympathetic nerve block therapy, can be curative. Even when RSD symptoms resolve, the extremity remains at risk for recurrence months to years later. Minor traumatic events can reactivate the RSD condition. In the majority of patients with symptoms lasting months, the RSD syndrome develops into a chronic and permanent disability affecting daily activities, ability to work, and social relationships.

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