Epithelioid Trophoblastic Tumor


D efinition A subset of extravillous trophoblastic tumor that is thought to arise from an extravillous (transitional) trophoblast that forms a transition from villous cytotrophoblast to mature extravillous trophoblast. These cells are found in the chorionic membrane, maternal surface of the placenta, and where intervillous fibrin is deposited.

Clinical Features

Epidemiology

  • Rare.

  • Occurs in reproductive-age women.

  • Epithelioid trophoblastic tumors (ETTs) are an unusual type of extravillous trophoblastic tumor.

  • Both ETTs and placental site trophoblastic tumors (PSTTs) are almost always seen following a term delivery.

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