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Chronic Villitis
D efinition — Maternal chronic inflammatory cells within terminal villi, not attributable to any known infection.
Clinical Features
Epidemiology
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Present in 5% to 10% of examined placentas.
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More often seen in women with autoimmune disorders such as systemic lupus erythematosus.
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Thought by some to be an autoimmune phenomenon, and some authors consider it a maternal-placental graft rejection.
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Others suspect that chronic villitis (CV) represents a response to an as-of-yet unidentified organism.
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