Introduction Cancer is a leading cause of death worldwide. Given the unmet need for more effective anticancer therapy, intense efforts have been invested in searching for better anticancer drugs in a more efficient manner. Pharmaceutical companies and academic investigators alike…
Acknowledgments A Ph.D. stipend of the Chinese Scholarship Council to G.Y. is gratefully acknowledged. Introduction The development of drug resistance, which eventually leads to therapy failure and tumor relapse, emerges as a major challenge in cancer treatment. Clinic drug resistance…
Introduction Lung cancer is one of the most common and serious types of cancer, which causes the highest cancer mortality among men and women worldwide. The two major types of lung cancers are small cell lung cancer (SCLC) and non-small…
Acknowledgments We want to apologize to all authors whose work could not be cited due to space restrictions/limitations in this chapter. Introduction Cancer in general is one of the leading causes of mortality worldwide [ ]. Pancreatic ductal adenocarcinoma (PDAC),…
Hepatocellular carcinoma Hepatocellular carcinoma (HCC) is a major health problem with devastating consequences associated with treatment failure. It has an estimated global incidence of more than 850,000 new cases annually [ ]. HCC is currently the second leading cause of…
Introduction Breast cancer is a major public health concern and a relevant mortality issue in young women worldwide [ ]. Mammary tumors are extremely heterogeneous at the histological, molecular, and systemic levels. To handle such variability, oncology researchers and clinicians…
Introduction Breast cancer is the most prevalent cancer in women worldwide, and despite tremendous research efforts, it remains the second leading cause of cancer-related mortalities among women ( ). According to the 2018 GLOBOCAN report, over 2 million new…
List of abbreviations 2-DG 2-Deoxyglucose 2-FDG 2-Fludeoxyglucose 3D Three direct-acting antivirals ABC7 Adjuvant for breast cancer treatment using seven repurposed drugs ABCG2 ATP-binding cassette superfamily G member 2 ADH Alcohol dehydrogenase ADRB Adrenoreceptor beta ALDH Aldehyde dehydrogenase AMP Adenosine monophosphate…
List of abbreviations ABPP Activity-based protein profiling ADR Adverse drug reactions AI Artificial intelligence AML Acute myeloid leukemia ANN Artificial neural networks ATC Anatomical therapeutic classification AUC Area under curve AUROC Area under the receiver operating characteristic curve BBB Brain–blood…
Introduction The 2018 Nobel Prize in Physiology or Medicine was awarded to two researchers for their discovery of immune checkpoint proteins [ ]. Although the discovery initiated the development of the revolutionary targeted immunotherapies, critical challenges remain to be addressed,…