Introduction to the mesenchymal stem cell Multipotent stem cells are of great interest in biomedical research, since they have the potential to produce all kinds of tissues that can be used to repair damaged organs. In a time when human…
Research highlights Bone is the primary target tissue for metastases in patients affected by breast and prostate cancers. Bone metastases represent the paradigm of the “seed and soil theory.” Osteomimicry refers to the capacity of CTCs to acquire a molecular…
Abbreviations (BMP) Bone morphogenic protein (CXCL) C-X-C motif ligand (CXCL12) C-X-C motif chemokine 12 (CXCR4) C-X-C chemokine receptor type 4 (DKK1) Dickkopf Wnt signaling pathway inhibitor 1 (FGFs) Fibroblast growth factors (HSC) Hematopoietic stem cell (IFNγ) Interferon γ (IGF) Insulin-like…
Introduction Breast cancer is a worldwide public health threat and the most common type of female malignancy. Bone metastasis is the primary cause of mortality of breast cancer patients [ ]. Metastasis to any organ is a life-threatening and commonly…
Introduction Histological analysis of bone is a critical step for the diagnosis of malignancies. It allows direct identification of malignant cells inside marrow spaces in case of bone metastases or hematological disorders. Bone biopsy is superior to marrow aspiration because…
Research highlights AI can integrate clinical information to stratify patients to personalized imaging procedures. AI can aid radiologists in the detection of tumors in other organ systems. Due to sparse data, the characterization of bone tumors is limited to date.…
Introduction The medical field, including medical imaging, is amassing data at an increasingly higher rate. Computer-based software, developed to automatically find patterns and infer unknown information from recorded data, is becoming a key component in both medical research and clinical…
Advantages of zebrafish models for cancer research Zebrafish is a preeminently suitable model organism for cancer research and has been shown to complement murine model systems to assay tumor cell malignancy, progression, and drug screening after xenotransplantation [ ]. A…
Introduction In human disease, bone metastasis is a slow process often developing years after the initial tumor is diagnosed and treated. Bone metastases are commonly only detected when patients present with late-stage symptomatic disease, at a point when extensive bone…
Acknowledgments We thank Ms Séverine (Université de Nantes, FR) for providing the micro-CT images and M Jérome Amiaud and Ms Céline Charrier (Université de Nantes, FR) for the histological preparation. You’re Reading a Preview Become a Clinical Tree membership for…