Cases of Diastolic Heart Failure


Case 1

35-Year-Old African American Man With Suspected Left Ventricular Hypertrophy

  • History: 35-year-old African American athlete referred for evaluation of suspected left ventricular hypertrophy based on an electrocardiogram (ECG) obtained during his annual screening. He is otherwise completely asymptomatic.

  • Past medical history: None

  • Past surgical history: Fractured left tibia

  • Social: Denies any smoking or alcohol consumption

  • Physical exam:

    • Pulse: 47 bpm, sinus rhythm

    • Blood pressure: 120/75 mmHg

    • Neck: No elevation of jugular venous pressure (JVP), no carotid bruits, no masses

    • Chest: Lungs are clear to auscultation

    • Cardiovascular: S 1 , S 2 normal, no murmurs

    • Abdomen: No tenderness, organomegaly, palpable masses, or bruits, normal bowel sounds

    • Extremities: No edema

ECG

LV-End Diastolic Dimensions M-Mode Parasternal Long-Axis.

Pulsed-wave Doppler LV Inflow.

Tissue Doppler Lateral Mitral Annulus.

Tissue Doppler Septal Mitral Annulus.

LA Volume.

Tricuspid Regurgitation on Continuous Wave Doppler.

Review Question

  • 1.

    Which of the following statements is true?

    • a.

      Diastolic function is normal.

    • b.

      There is grade 1 diastolic dysfunction.

    • c.

      The E/A ratio of 2.68 is concerning for restrictive physiology.

    • d.

      Family members should be screened for hypertrophic cardiomyopathy.

Case 2

65-Year-Old Caucasian Female Referred for Poorly Controlled Hypertension

  • History: 65-year-old Caucasian female was referred by her primary care physician for poorly controlled essential hypertension. She reports mild exertional dyspnea. She denies chest pain, orthopnea, paroxysmal nocturnal dyspnea, or lower extremity edema.

  • Past medical history: Normocytic anemia, essential hypertension

  • Past surgical history: None

  • Social: Occasional alcohol and social smoker

  • Physical exam:

    • Pulse: 75 bpm, sinus rhythm

    • Blood pressure: 175/92 mmHg

    • Neck: JVP at the level of the jaw, no carotid bruits, no masses

    • Chest: Decreased air entry to the bases

    • Cardiovascular: S 1 , S 2 normal, grade II/VI systolic murmur at the left sternal border

    • Abdomen: No tenderness, organomegaly, palpable masses or bruits, normal bowel sounds

    • Extremities: Mild bilateral pitting edema

ECG: Sinus Rhythm.

LV End-Diastolic Dimensions, M Mode Parasternal Long Axis.

Pulsed-wave Doppler LV Inflow.

Tissue Doppler Lateral Mitral Annulus.

Tissue Doppler Medial Mitral Annulus.

LA Volume.

Tricuspid Regurgitation on Continuous Wave Doppler.

Review Question

  • 2.

    Which of the following statements is true?

    • a.

      Diastolic function is normal.

    • b.

      There is grade 1 diastolic dysfunction.

    • c.

      The E/e′ ratio of 17.9 signifies elevated LA pressures.

    • d.

      There is restrictive filling pattern.

Case 3

47-Year-Old African American Man With Multiple Myeloma Being Evaluated for Lower Extremity Edema and Dyspnea

  • History: 47-year-old African American man was recently diagnosed with multiple myeloma (kappa light chain) when being investigated for anemia. His anemia has since resolved, but he is now complaining of external dyspnea, palpitations, and lower leg edema. An echocardiogram was ordered.

  • Past medical history: Multiple myeloma, anemia, asthma, dyslipidemia, pleural effusion of unknown etiology, carpel tunnel

  • Past surgical history: None

  • Social: No alcohol or smoking

  • Current medications: Budesonide, torsemide, eplerenone, bortezomib-dexamethasone

  • Physical exam:

    • Pulse: 75 bpm sinus rhythm

    • Blood pressure: 125/81 mmHg

    • Neck: JVP at the level of the jaw, no carotid bruits, no masses

    • Chest: Crackles at the base of the right lung

    • Cardiovascular: S 1 , S 2 normal, S 3 , no murmur

    • Abdomen: No tenderness, organomegaly, palpable masses, or bruits, normal bowel sounds

    • Extremities: Mild bilateral pitting edema

ECG

LV End-Diastolic Diameter, 2-D Parasternal Long Axis.

Pulsed-wave Doppler LV Inflow.

Tissue Doppler Lateral Mitral Annulus.

Tissue Doppler Medial Mitral Annulus.

LA Volume.

Tricuspid Regurgitation on Continuous Wave Doppler.

Global Longitudinal Strain.

Review Questions

  • 3.

    Which of the following statements is false?

    • a.

      There is grade 3 diastolic dysfunction.

    • b.

      There are increased left atrial pressures.

    • c.

      There is grade 2 diastolic dysfunction.

    • d.

      Basal to midventricular systolic dysfunction with relative sparing of the apex is a specific sign for cardiac amyloidosis.

Case 4

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