Becker nevus


Evidence Levels: A Double-blind study B Clinical trial ≥ 20 subjects C Clinical trial < 20 subjects D Series ≥ 5 subjects E Anecdotal case reports

Becker nevus, also called pigmentary hairy epidermal nevus, is a cutaneous hamartoma that may have increased epidermal pigmentation (melanocyte), appendageal (hair follicle), and dermal (smooth muscle) components. Becker nevus is first noticed around puberty on the shoulders and chest but may also be congenital and involve any area of the body with a sixfold greater prevalence in men. This direct relationship to puberty is thought to be due to the increased density of androgen receptors within the Becker nevus.

Management Strategy

Becker nevus is asymptomatic and may come to the attention of a physician for cosmetic or diagnostic purposes. Management of asymptomatic benign lesion should comprise confirmation of diagnosis and an evaluation for any associated pathology such as developmental abnormalities that can accompany Becker nevus or within the spectrum of Becker nevus syndrome. Reported cutaneous associations include an acneiform eruption, eczematous dermatitis, hypohidrosis, lichen planus, localized lipoatrophy, localized scleroderma, polythelia, psoriasiform dermatitis, unilateral breast hypoplasia, osteoma cutis, capillary malformations, dermal melanocytosis, and neurofibromatosis type-1. Musculoskeletal associations include limb asymmetry, pectus excavatum/carinatum, scoliosis, and other vertebral defects.

Association of Becker nevus with cutaneous malignancies, including basal and squamous cell carcinoma, was described separately in three young individuals without significant risk factors. Although melanoma has been described in patients with Becker nevus, the risk of malignant transformation of the nevus itself is very low, thus enhanced screening is unnecessary.

The treatment of a Becker nevus depends on multiple factors including skin type, desired treatment end point, pigmentary involvement, hypertrichosis, and extent of musculoskeletal involvement. Becker nevus is primarily treated for pigment or hair removal with lasers. Surgical excision, oral and topical antiandrogens, topical depigmenting agents, and topical glycolic acid and a variety of light and laser sources have also been used to treat both the pigmentary and musculoskeletal manifestations of Becker nevus.

Postzygotic mutations in beta-actin are associated with Becker’s nevus and Becker’s nevus syndrome

Cai ED, Sun BK, Chiang A, et al. J Invest Dermatol 2017; 137: 1795–8.

A postzygotic lethal mutation in ACTB, a gene encoding beta-actin, underlies the development of Becker nevi in both isolated Becker nevi and Becker nevus syndrome. These mutations potentiate the Hedgehog signaling pathway, thereby disrupting hair follicle and pilar muscle development causing this clinical phenotype.

Specific Investigations

  • Skin biopsy – although skin biopsy is diagnostic, it is often unnecessary

  • Inquire about family history and evaluate for associated pathology

  • Dermoscopy – reticulated pigment network, focal hypopigmentation, furrow hypopigmentation, hair follicles, perifollicular hypopigmentation, and vessels are the main dermoscopic features

First-Line Therapies

Treatment can be divided into two components:

  • Reduction of hyperpigmentation

  • Removal of hair

Reduction of Hyperpigmentation

  • Intense pulsed light

  • B

  • Erbium:YAG laser

  • C

  • Long-pulsed alexandrite laser

  • D

  • Long-pulsed Nd:YAG

  • D

  • Erbium-doped fiber laser (Fraxel)

  • D

Intense pulsed light for treatment of Becker’s nevus

Wu PR, Lan-Ju L, Zhang Y-X, et al. J Dermatolog Treat 2019: 2: 1–6.

A prospective study of 24 patients with Becker nevus treated with intense pulsed light at a filter of 590 nm. Treatments were repeated a mean of five times with 3-month duration between treatments. The majority of patients experienced at least 50% improvement in their lesion in both hyperpigmentation and hypertrichosis without signs of repigmentation at 6-month follow-up.

Efficacy and safety of short-pulse erbium:yttrium aluminum garnet laser treatment of Becker’s nevus in Saudi patients: a pilot study

Al-Saif F, Al-Mekhadab E, Al-Saif H. Int J Health Sci (Qassim) 2017; 11: 14–7.

This study evaluated the use of 2940 nm Er:YAG to treat pigmentation of Becker nevus in a series of seven patients. The study showed improvement in pigmentation in all seven patients with no infections, hypertrophic, or keloids posttreatment and no recurrence at 1 year.

Lasers for Becker’s nevus

Zhong Y, Yang B, Huang L , et al. Lasers Med Sci 2019; 34: 1071–79.

This paper reviewed the efficacy of lasers from the range of 504–10,600 nm to treat Becker nevi. If a single laser is desired to treat both the pigmentary changes and hypertrichosis changes seen in Becker’s nevus, a diode laser (808/810 nm) may be optimal over Nd:YAG laser (1064 nm) in order to minimize damage to uninvolved tissue. The greatest clinical efficacy for pigmentary changes was seen with Er:YAG 2940 nm laser after only one treatment with 1–5 passes.

Becker’s naevus: a comparative study between Erbium:YAG and Q-switched Neodymium:YAG; clinical and histopathological findings

Trelles MA, Allones I, Moreno-Arias GA, et al. Br J Dermatol 2005; 152: 308–13.

Twenty-two patients with Becker nevi were studied, 11 with each laser. Both Erbium:YAG and Nd:YAG safely treated the lesions. For pigment removal, one pass with Erbium:YAG was superior to three treatment sessions with Nd:YAG.

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