Valvular Heart Disease: A Companion to Braunwald's Heart Disease

Inside back cover

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Valvular heart disease in pregnancy

Key points Pregnancy increases cardiac output and intravascular volume, which increases gradients across stenotic lesions and can exacerbate heart failure in patients with severe valvular stenosis. Intravascular volume increases in the immediate postpartum period, and high-risk patients require 48 to…

Management of bioprosthetic valve degeneration

Key points The choice of surgical valve replacement or transcatheter valve-in-valve (VIV) implantation for bioprosthetic valve failure depends on careful consideration of patient characteristics and surgical valve and anatomic parameters by a multidisciplinary heart valve team. Clinical outcomes after a…

Prosthetic heart valves

Key points The need for heart valve replacement surgery marks a major milestone in the natural history of valve disease and mandates establishment of a schedule for clinical and echocardiographic surveillance. Surgical repair, especially for primary mitral regurgitation, is preferred…

Infective endocarditis

Key points Infective endocarditis (IE) is a subacute or acute infection of a heart valve, endocardial surface, prosthetic valve or material, or cardiac implantable electronic device (CIED). Despite improvements in IE diagnosis and treatment, in-hospital mortality has not decreased and…

Pulmonic valve disease in adults

Key points Congenital valvular pulmonic stenosis (PS) that is mild in severity is well tolerated and has a benign natural history. Balloon angioplasty is the first-line treatment for severe valvular PS, especially for doming pulmonic valves. Double-chambered right ventricle is…

Diseases of the tricuspid valve

Key points Tricuspid regurgitation (TR) is most frequently functional, not related to primary tricuspid leaflet pathology but secondary to another disease process that produces right ventricular dilation, distortion of the subvalvular apparatus, tricuspid annular dilation, or a combination of these.…

Intraoperative echocardiography for mitral valve surgery

Key points Mitral regurgitation (MR) and mitral stenosis (MS) may result from abnormalities of the mitral valvular complex—leaflets, annulus, chordae, and papillary muscles—and the left atrium and ventricle. Intraoperative echocardiography is a vital diagnostic technique for mitral valve (MV) surgery…

Imaging guidance of transcatheter mitral valve procedures

Key points The field of structural heart disease interventions is expanding rapidly. Advances in cardiac imaging are playing a central role in patient selection, imaging guidance, and follow-up of patients undergoing transcatheter mitral valve procedures (TCMVPs). Three-dimensional transesophageal echocardiography has…

Transcatheter mitral valve repair and replacement

Key points The risks of surgery for severe mitral regurgitation (MR) in elderly patients and those with medical comorbidities, particularly with consideration of patient preference for quick recovery, have stimulated attempts to develop less invasive solutions. Unlike the extensive toolbox…