Definition A late-onset, autosomal dominant disorder characterized by the progressive development of innumerable cysts in the kidney, leading to renal insufficiency. Associated with mutations in the PKD1 gene on chromosome 16 (16q13.3) in 85% of patients, or the PKD2 gene…
Definition Rare, early onset, autosomal recessive inherited polycystic kidney disease Associated with single gene ( PKHD1 ) mutation on chromosome 6p21–23 PKHD1 gene encodes polyductin/fibrocystin Clinical features You’re Reading a Preview Become a Clinical Tree membership for Full access and…
Definition Localized cystic disease (LCD) involves part of a, or rarely entire, kidney with multiple cysts surrounded by normal renal parenchyma. Also known as unilateral cystic disease or segmental cystic disease. Clinical features Epidemiology Rare Median age 33.3 (range 18–56)…
Definition A congenital developmental renal malformation resulting from abnormal nephrogenesis related to the inability of the ureteric bud to communicate with the metanephric blastema Clinical features Epidemiology Relatively common, affecting 1 in 1000 of the general population. About 10% of…
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Definition Adenocarcinoma originating in other organs with secondary involvement of the bladder through direct extension or via lymphatic or vascular spread Clinical features You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become…
Definition Secondary involvement of the urinary bladder by prostatic carcinoma, most often by direct extension Clinical features You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member.…
Overview Bladder cancers are heterogeneous at the molecular level with two distinct oncogenic pathways. Recent genomic and molecular studies have been focused on muscle invasive bladder cancer (MIBC). Molecular classification based on genetic and molecular alterations characterized by multiple platforms…
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Definition Neoplasm derived from the paraganglial cells in the bladder wall Clinical features You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in here