Introduction As the role of fine-needle aspiration biopsy (FNAB) in the evaluation of focal liver lesions has evolved, it has presented new challenges. , Advances in dynamic imaging modalities have obviated the need for tissue confirmation in clinically classic cases…
Introduction Identification of the molecular pathways altered in benign and malignant hepatocellular tumors has significantly increased our understanding of hepatocellular tumorigenesis. The immunohistochemical markers derived from these molecular alterations have been useful in clinical pathology practice, contributing to accurate diagnosis…
Liver Biopsy Specimens Histopathological examination of liver tissue by needle biopsy remains an integral part of the management of liver diseases, as morphology is of critical importance for synthesizing clinical and laboratory testing findings into cogent understanding of a patient’s…
Introduction The goal of this chapter is to provide a structured and efficacious approach to evaluation of nontargeted liver biopsy specimens (i.e., “medical” liver biopsies). The process begins with recognizing the predominant pattern of injury and then, by careful correlation…
Introduction Since both the distal common bile duct and the main pancreatic duct converge at the level of the ampulla, ampullary tumors ( Box 42.1 ) may obstruct two organs, which may lead to early onset of symptoms. However, the…
Introduction And Classification Probably the most common problems in the diagnosis of pancreatic neoplasms are the distinction of invasive ductal adenocarcinoma from its mimics and the preoperative evaluation of cystic lesions, which are increasingly recognized. Solid, cellular pancreatic neoplasms present…
Introduction This chapter discusses a range of inflammatory and other nonneoplastic diseases of the pancreas, with a focus on variants of chronic pancreatitis that mimic pancreatic neoplasia including autoimmune pancreatitis (AIP) and paraduodenal pancreatitis. In the past, a generic diagnosis…
Acknowledgment We thank Drs. Kerem Ozcan and Aslihan Yavas for their contributions in the preparation of this chapter. Introduction As discussed in other chapters, gallstones and inflammatory disorders constitute the vast majority of biliary tract pathology. Neoplasms and tumor-like lesions…
Introduction The gallbladder is a surgical pathology specimen normally obtained by laparoscopic cholecystectomy or laparotomy. Historically, surgical pathologists have dedicated little time to the gross and microscopic examination of the gallbladder because they have believed that the information derived from…
Introduction Developmental, congenital, hereditary, and structural disorders that can affect the gallbladder, extrahepatic biliary tract, and pancreas are listed in Box 37.1 . This chapter focuses primarily on the few disorders that are encountered peripherally or directly in surgical pathology.…