Epidemiology and Etiology Hepatocellular carcinoma (HCC) is the sixth most common malignancy in the world and the fastest growing cause of cancer-related death. This is in part due to endemic viral hepatitis in developing countries and the epidemic of obesity…
The widespread use and progress in modern imaging modalities have led to an increase in the incidental finding of asymptomatic benign hepatic lesions, including cystic and solid tumors. In contrast to most cystic lesions, the latter group is composed of…
Drug-induced liver injury (DILI) is a frequent cause of liver injury. It is the most frequent reason for withdrawal from the market of an approved drug and accounts for one-third to one-half of the cases of acute liver failure in…
The topic vascular diseases of the liver encompasses an array of disparate clinicopathologic entities, with the common thread that they specifically affect the hepatic vasculature. They can be arbitrarily classified into those that involve the hepatic artery and its branches,…
The failing liver represents a syndrome with profound morbidity and mortality. The morbidity of liver failure is secondary to the tremendous decline in metabolic and synthetic functions inherent to the liver. With the decline in metabolic activity, accumulation of toxic…
Liver transplantation has now been the accepted standard of care for the treatment of end-stage liver disease and related conditions for more than 25 years. Although it was in 1963 that Thomas Starzl and his team performed the first successful…
The liver is a common site for both primary and metastatic oncologic disease. Primary hepatocellular carcinoma (HCC) has an annual incidence of 6 per 100,000 in the United States. Worldwide HCC is the second leading cause of cancer-related death in…
The field of hepatobiliary surgery has evolved dramatically in the past few decades, with improved understanding of the anatomic segments of the liver, advancements in modern imaging techniques, better operative instrumentation, and improved anesthesia care, as well as postoperative management.…
Liver Biopsy Percutaneous and Transjugular Liver Biopsy Liver biopsy was originally described by Ehrlich in 1883 to determine glycogen stores in patients with diabetes. A variety of approaches and techniques have been described for performing liver biopsy, including percutaneous, transjugular,…
Despite improvements in motor vehicle safety and altered patterns in trauma epidemiology over the past 20 years, the liver remains the most commonly injured intraabdominal organ. While the treatment of hepatic injuries has evolved over the past 100 years, areas…