Introduction This chapter will cover primarily those entities that come to the attention of the surgical pathologist; therefore most non-neoplastic entities of the intraocular tissues will be excluded. Dystrophies and degenerative conditions of the cornea also represent a complex subject…
Overview of Sellar Region Masses The overwhelming majority of sellar region masses are pituitary adenomas (85%), followed by craniopharyngioma (3%), Rathke cleft cyst (2%), meningioma (1%), and metastases (0.5%); other lesions such as hypophysitis, pituicytoma, spindle cell oncocytoma, and granular…
Normal Anatomy Dauntingly complex and characterized by extraordinary variation in regional architecture, the gross and microscopic anatomy of the human central nervous system (CNS) cannot be surveyed here in detail. Instead, a brief review of anatomic landmarks and topographic relationships…
Heart Surgical pathology specimens received from cardiovascular procedures have evolved in parallel to advances and general trends in cardiovascular surgery over recent decades. Methods have been devised to relieve aortic, mitral, and pulmonary valvular stenosis (often by replacement with a…
Normal Anatomy Soft tissue is loosely defined as the complex of nonepithelial extraskeletal structures of the body exclusive of the supportive tissue of the various organs and the hematopoietic/lymphoid tissue. It is composed of fibrous (connective) tissue, adipose tissue, skeletal…
Bone Normal Anatomy Adult bones are classified according to their shape into long (such as femur), flat (such as pelvis), and short (such as bones of hand and feet). Long bones (and some short bones, such as metacarpal bones) are…
Biopsy Procedure and Processing of Specimen Trephine biopsy of the bone marrow has wide application in clinical medicine; its greatest utility is in the evaluation of patients with malignant lymphoma, acute leukemias, myeloproliferative neoplasms (MPNs), myelodysplastic syndromes (MDSs), metastatic tumor,…
Normal Anatomy The normal spleen serves as a lymphoid organ as well as a filtering organ. While fetal hematopoiesis occurs in the spleen, the spleen is not normally a hematopoietic organ after birth but may contain evidence of extramedullary hematopoiesis…
Normal Anatomy The lymph node is one of the major anatomic components of the immune system. The three major regions of a lymph node are the cortex , paracortex , and medulla ( Fig. 37.1A ). The cortex is situated…
Normal Anatomy The breast or mammary gland is covered by skin and subcutaneous tissue and rests on the pectoralis muscle, from which it is separated by a fascial layer. The morphofunctional unit of the breast is a complex branching structure…