Acknowledgments This work was supported by Austrian Research Promotion Agency (822782/THERAPEP) and the Children's Cancer Foundation Salzburg. Introduction Most cancer cells reprogram their metabolism and pathways of nutrient acquisition to ensure high levels of energy supply and biomass production, while…
Acknowledgments This work is founded by The Italian Neuroblastoma Foundation “Fondazione Italiana per la Lotta al Neuroblastoma”. The authors would like to thank Carlo Zanon for his critical revision of the chapter. Introduction From the previous chapters, we have learned…
Acknowledgments This work is dedicated to the memory of Dr. Vito Pistoia, a leading expert in this field. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a…
Introduction Cancer immunotherapy has been hailed as a potential “game changer” in the treatment of cancer. However, the number of antigen targets proven effective remains limited and is restricted to protein antigens, with the exception of Dinutuximab, a chimeric antibody…
Introduction Major strides have been made in targeted cancer therapy over the past decades due to better understanding of underlying cancer biology, identification of cancer vulnerabilities, and integration of multiple therapy approaches . These advances have led to the development…
Introduction Neuroblastoma is a sympathetic nervous system malignant tumor, which is derived from the neural crest cells and constitutes 7%–11% of the total number of childhood malignant tumors, taking fourth place in the structure of cancer morbidity after acute leukemia,…
Introduction Neuroblastoma is often used as a collective term for all types of peripheral neuroblastic tumors of neural crest origin and includes Neuroblastoma, Ganglioneuroblastoma, and Ganglioneuroma. Historically tumors in this group were described as “enigmatic” because of their unique and…