Physical Address
304 North Cardinal St.
Dorchester Center, MA 02124
Inside back cover
You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in here
Multiomic-based therapeutics: The future
Key points 1. Integration of different “omics” such as microbiome, metabolome, and proteome provides opportunities to more closely evaluate mechanisms of action leading to disease processes as well as provide biomarkers for future diagnostics and therapeutics. 2. Technologies are being…
GI surgical conditions in the NICU
Key points 1. Long-term survival of children with intestinal failure has significantly improved with advances in management including the establishment of interdisciplinary intestinal rehabilitation centers. 2. A fundamental goal of intestinal failure management is weaning from parenteral nutrition (i.e., attaining…
The future of neonatal nutrition: Further research and investment, new products
Key points 1. Many of today’s nutritional guidelines for preterm infants are based on clinical judgment, an evidence base that relies on observational and randomized trials, and some basic scientific studies that aim to meet the needs of the mean…
International perspective: Management of nutrition in preterm infants in settings with limited resources
Key points 1. Globally it is estimated that 15 million infants are born preterm and most of them are delivered in low- and middle-income countries. Nutritional interventions may be costly, increasing the financial burden of their care, or may be…
Science-based strategies for providing nutrition for high-risk neonates
Key points 1. Optimization of the delivery of nutrition to the high-risk infant is essential for ideal growth and development. 2. Standardizing nutrition guidelines based on the current best evidence leads to reduced risk of infection and necrotizing enterocolitis (NEC),…
Different forms of intestinal injury: Moving beyond NEC
Key points 1. Necrotizing enterocolitis (NEC) is a poorly defined umbrella diagnosis for what is more likely a heterogenous group of acquired neonatal intestinal injuries. 2. Multiple criteria exist for NEC, of varying sensitivities and specificities. However, much of the…
Donor milk nutrition for the preterm infant: Current standards, uses, and transitions
Key points 1. Pasteurized donor human milk is the preferred alternative feeding source when maternal milk is not available for preterm and low-birth-weight infants. 2. Holder pasteurization, freezing, and handling of donor human milk leads to decreased macronutrient content by…
Human milk bioactives and roles in the GI tract
Key points In addition to nutrients, human milk contains myriad bioactive components that promote development of neonatal intestinal immunity. A range of bioactive proteins in human milk function in protection against infection, immunomodulation, and nutrient utilization. Human milk growth factors…
Monitoring of feeding tolerance in preterm infants
Key points 1. The current definition of feeding intolerance is based on nonspecific clinical signs and symptoms. 2. Research on feeding intolerance is limited by the lack of a more objective definition. 3. Current methods to monitor for feeding tolerance…