Development of the human hemostatic system begins in utero and continues until well after birth. As a result, functional levels of many of the procoagulants, coagulation inhibitors, fibrinolytic components, and platelet-associated factors differ from those of older children and adults,…
Introduction * URL referenced in this chapter includes: Online Mendelian Inheritance in Man (OMIM), . Elevation of the serum bilirubin level is a common, if not universal, finding during the first week of life and has been reviewed elsewhere.…
Historical Aspects Whereas many serious complications of pregnancy were well known in antiquity, maternofetal blood group incompatibility was recognized more recently. Against the high perinatal mortality prevailing until the mid-twentieth century, deaths from hemolytic disease were of little statistical significance,…
Introduction At no other time in the life of a patient is the physician confronted with as many diagnostic considerations in the interpretation of apparent disturbances of the erythrocyte as during the neonatal period. Neonatal erythrocytes are fundamentally different from…
This chapter offers a review of the anatomy and physiology of normal hematopoiesis that is intended to provide a basis for understanding the marrow failure syndromes described at length in the following chapter. In this chapter we briefly discuss the…