Kidney cancer is one of the 10 most common cancers in the United States in both men and women. A number of subtypes of kidney cancer exist. Historically these subtypes have been recognized based on their histological appearance, but it…
Prostate cancer is the most common noncutaneous malignancy and the second leading cause of cancer death in men in the United States. Prostate-specific antigen (PSA) screening began in the late 1980s and dramatically increased the diagnosis of this disease. An…
Acknowledgments These studies were supported in part by a grant from the National Cancer Institute R01 CA135354 , by the M.D. Anderson SPORE in Ovarian Cancer NCI P50 CA83639, the Shared Resources of the M.D. Anderson CCSG NCI P30 CA16672,…
Acknowledgments This work was supported in part by research grants from the NIH/National Cancer Institute R01CA94118 (AVL), R01097213 (SO), the Breast Cancer Research Foundation (SO and NED), Susan G. Komen for the Cure (AVL), the Pennsylvania Department of Health (AVL…
The most common exocrine pancreatic neoplasm is pancreatic ductal adenocarcinoma, which accounts for more than 95% of all pancreatic malignancies. Other pancreatic malignant neoplasms include acinar cell carcinoma, serous cystadenocarcinoma, mucinous cystadenocarcinoma, intraductal papillary-mucinous neoplasm, osteoclast-like giant cell tumor, solid…
Colorectal cancer (CRC) development is a complex process. Causal agents and mechanisms include environmental and dietary factors and inherited and somatic mutations. Great progress has been made over the past 30 years toward defining the constellation of molecular alterations contributing…
Epidemiology and Clinical Considerations Head and neck squamous cell carcinoma (HNSCC) arises in the oral cavity, oropharynx, hypopharynx, and larynx. It accounts for more than 90% of the cancers of the head and neck and is the sixth most common…
Acknowledgments We thank the many current and past members of the Minna lab for their contributions to lung cancer translational research and our especially our long-term collaborator, Dr. Adi Gazdar. Also we apologize to other investigators for the omission of…
Introduction The cancers arising from the esophageal mucosa, primarily esophageal adenocarcinoma (EAC) and esophageal squamous-cell carcinoma (ESCC), are clinically some of the most devastating and lethal cancers in the world. Collectively, they are the eighth most common cancer diagnosed worldwide,…
Acknowledgments Dr. G. Tonon acknowledges the support from the Associazione Italiana per la Ricerca sul Cancro (AIRC), the Association for International Cancer Research (AICR), and the Cariplo Foundation and is a recipient of a Marie Curie International Reintegration Grant. Dr.…