General information Proguanil is one of the antimalarial drugs most widely used for prophylactic purposes, usually in combination with chloroquine or atovaquone in malaria prophylaxis, and with atovaquone in malaria treatment [ ]. A biguanide, it is rapidly absorbed in…
See also Non-steroidal anti-inflammatory drugs (NSAIDs) General information Proglumetacin, an indoleacetic acid derivative, is a non-steroidal anti-inflammatory drug and can cause gastrointestinal adverse reactions: in different trials 18–41% of patients had adverse reactions, although not to the extent that they…
See also Hormonal contraceptives – emergency contraception ; Hormonal contraceptives—progestogen implants ; Hormonal contraceptives—progestogen injections General information Most aspects of progestogens are dealt with in the monograph on hormonal contraception. For a complete account of the adverse effects of progestogens,…
General information Progabide acts, together with its metabolites, as an agonist at both GABA A and GABA B receptors. It has been used in the treatment of spasticity [ , ], epilepsy and movement disorders [ , ], and benign…
See also Anticholinergic drugs General information Procyclidine is an anticholinergic drug [ ]. The usual oral dose, 20–30 mg/day, is likely to produce only mild anticholinergic adverse reactions, but involuntary movements, with chewing and sucking, have been described in some…
See also Neuroleptic drugs General information Prochlorperazine is a phenothiazine derivative. Organs and systems Cardiovascular There was an association between the use of antipsychotic drugs and the risk of venous thromboembolism in a large nested case-control study using the UK…
See also Cytotoxic and immunosuppressant drugs General information Procarbazine is an alkylating agent that has been used in the treatment of Hodgkin’s disease in regimens such as MOPP (chlormethine (mechlorethamine), vincristine (Oncovin), procarbazine, and prednisolone) and BEACOPP (bleomycin, etoposide, doxorubicin…
See also Anesthetics, local ; Chloroprocaine General information Procaine is an aminoester local anesthetic. It is most widely used as a component of procaine penicillin. Organs and systems You’re Reading a Preview Become a Clinical Tree membership for Full access…
See also Acecainide General information Procainamide is a Class Ia antidysrhythmic drug with electrophysiological actions similar to those of quinidine [ ]. Adverse reactions to procainamide are predominantly on the heart. It causes reduced myocardial contractility and hypotension and prolongs…
General information Probucol is a lipid-modifying drug that is stored in fat, from which it is slowly released; it can still be detected in plasma 6 months after the end of treatment. Adverse reactions to probucol have been reviewed […