Hematopoietic Cell Transplant Preparative Regimens Goals of the Preparative Regimen Hematopoietic cell transplant (HCT) is a therapy that has the potential to cure or prolong the life of patients with hematologic malignancies as well as certain solid tumors and nonmalignant…
Introduction The introduction of chimeric antigen receptor (CAR) T-cell therapies represents the culmination of a decades-long journey to harness the immune system and exploit the antitumoral potential of immune cells to treat cancer. The first clinical experiences describing the administration…
Introduction The first successful cord blood transplantation (CBT) was performed by Dr. Gluckman, Dr. Broxmeyer, and their colleagues for a patient with Fanconi anemia in 1989. Since then, the application of CBT has broadened to include both malignant and nonmalignant…
Introduction Allogeneic hematopoietic cell transplantation (allo-HCT) is a curative treatment for various hematologic and immunologic disorders. Historically, selection of a suitable allo-HCT donor relied exclusively on degree of human leukocyte antigen (HLA) matching between the donor and the recipient to…
Blood products are essential during the peritransplant period. Patients receiving hematopoietic cell transplantation (HCT) require extensive transfusion support until appropriate platelet and red blood cell (RBC) engraftment ensures. The platelet lineage is considered engrafted when a patient’s platelet count is…
Introduction Hematopoietic cell transplantation (HCT) remains an essential therapeutic intervention for several high-risk hematologic neoplasms. HCT leads to durable responses and remissions for plasma cell neoplasms and indolent lymphomas and can be curative for aggressive lymphomas, acute leukemias, myelodysplastic syndromes,…
Elements of Bayesian Statistics The main objects in a statistical model are observable data, which may include one or more outcomes, Y, possibly a vector, X, of patient covariates and treatments, and a parameter vector, θ. Parameters are unobserved conceptual…
Introduction The use of hematopoietic stem cells (HSCs) following conditioning chemotherapy in transplantation serves an important role to restore normal hematopoiesis and immune function. In allogeneic hematopoietic cell transplantation, the transplanted immune system has the additional therapeutic benefit of surveillance…
Introduction The human leukocyte antigen (HLA) system is the major histocompatibility complex (MHC) gene in humans. The HLA gene complex comprises about 3.6 Mb deoxyribonucleic acid (DNA) located on the short arm of chromosome 6 (6p21.3). It received its name…
Hematopoietic transplantation, commonly termed hematopoietic cell transplantation (HCT), involves engraftment of donor hematopoietic stem cells with subsequent regeneration of the blood and immune system. Transplants can be from another individual ( allogeneic ), a genetically identical twin ( syngeneic ),…