Personality disorders are some of the most common comorbid psychiatric conditions in major depressive disorder (MDD). The combination of MDD and personality disorders provides a real challenge to clinicians, as treatment of patients with these comorbid conditions is hampered by…
Part I: Identification Depression is a debilitating illness. The World Health Organization reports that globally 264 million people of all ages suffer from depression. The National Institute of Health reports that about 7% of all adults in the United States…
Introduction There has been a considerable increase in the number of older individuals in the United States, with those over the age of 85 representing the fastest growing segment of the population ( ). The global population has also seen…
Introduction Treatment-resistant depression in children and adolescents is defined as clinically significant depression that has not responded to treatment with a selective serotonin reuptake (SSRI) for at least 8 weeks by the TORDIA (Treatment of SSRI-Resistant Depression in Adolescents) trial…
Introduction Depressive symptoms are present during almost 70% of the symptomatic period in bipolar disorder patients (BD) ( ). Overall, patients with BD spent more than one-third of the time with subsyndromal or syndromal depression (17.6% and 18.4%, respectively, for…
Disclosures Dr. Jesse Wright is an author of the Good Days Ahead (GDA) computer program used in an investigation cited in this article, has an equity interest, and serves as a consultant to Mindstreet, Inc. developer and distributors of GDA.…
Introduction Major depressive disorder with psychotic features, or psychotic depression, is a serious psychiatric illness that presents with a combination of depressed mood and psychosis. The psychosis commonly manifests through nihilistic-type delusions with overly self-critical beliefs, severe guilt, paranoia, and…
Acknowledgments Interventional Psychiatry Program in the Department of Psychiatry and Behavioral Science at the University of Minnesota. Introduction The use of somatic interventions to control or treat mental symptoms dates back to ancient times ( ; ; ). Evidence for…
Introduction Neurosurgical interventions for the treatment of psychiatric illnesses have been used since the dawn of the somatic treatments in neuropsychiatry ( ). The use of surgery in psychiatry existed before there were effective pharmacological strategies, such as antidepressants or…
History Interest in the effects of vagus nerve stimulation (VNS) on the central nervous system began in the early 20th century, with Bailey and Bremer demonstrating in 1938 that electrical stimulation of the vagus nerve of cats resulted in increased…