KEY FACTS Terminology Malignant primary CNS neoplasm primarily composed of B lymphocytes (PCNSL) Imaging Best diagnostic clue: Enhancing lesion(s) within basal ganglia &/or periventricular white matter 60-80% supratentorial Often involve, cross corpus callosum Frequently contact, extend along ependymal surfaces Classically…
KEY FACTS Terminology Hemangioblastoma (HGBL): Highly vascular tumor of adults most commonly found in posterior fossa (PF), spinal cord 25-40% of HGBLs in von Hippel-Lindau disease (VHL) Imaging Best diagnostic clue: Adult with cerebellar mass with cyst and enhancing mural…
KEY FACTS Terminology Medulloblastoma (MB) Malignant, invasive, highly cellular embryonal tumor 4 distinct MB molecular subgroups Wingless (WNT) Sonic hedgehog (SHH) Group 3 Group 4 Imaging MB subgroups arise in different locations Midline (4th ventricle) – Predominately (but not exclusively)…
KEY FACTS Terminology Intracranial germ cell tumor (iGCT) iGCTs are intracranial homologue of gonadal germinomas (ovarian dysgerminoma, testicular seminoma) Imaging Most common: In/near midline (80-90%) Pineal region ~ 50-65% Suprasellar ~ 25-35% Less common: Basal ganglia/thalami ~ 5-10% 20% multiple…
KEY FACTS Terminology Primary parenchymal neoplasm of pineal gland Intermediate in malignancy between pineoblastoma and pineocytoma Imaging General features Aggressive-looking pineal mass in adult Extension into adjacent structures (ventricles, thalami) is common Lobulated, moderately vascular Size varies from small (<…
KEY FACTS Terminology Pineocytoma (PC), pineal parenchymal tumor (PPT) PCs are composed of small, uniform, mature cells Cells resemble pineocytes Imaging General features: Circumscribed, enhancing pineal mass May mimic benign pineal cyst or PPT of intermediate differentiation (PPTID) Typically <…
KEY FACTS Terminology Central neurocytoma (CN) = intraventricular neuroepithelial tumor with neuronal differentiation Imaging Best diagnostic clue: “Bubbly” mass in frontal horn or body of lateral ventricle May involve 3rd ventricle CT: Usually mixed solid and cystic mass with calcification…
KEY FACTS Terminology Dysembryoplastic neuroepithelial tumor (DNET) Benign mixed glial-neuronal neoplasm Frequently associated with cortical dysplasia Imaging May occur in any region of supratentorial cortex Temporal lobe most common, followed by frontal lobe Mass frequently “points” toward ventricle Sharply demarcated,…
KEY FACTS Terminology Well-differentiated, slowly growing neuroepithelial tumor composed of neoplastic ganglion cells and neoplastic glial cells Most common neoplastic cause of temporal lobe epilepsy (TLE) Imaging Best diagnostic clue: Partially cystic, enhancing, cortically based mass in child/young adult with…
KEY FACTS Terminology Choroid plexus tumor (CPT) 3 types of CPTs – Choroid plexus papilloma (CPP) (WHO grade I) – Atypical CPP (aCPP) (grade II) – Choroid plexus carcinoma (CPCa) (grade III) Imaging Classic: Child with enhancing lobulated (cauliflower-like) mass…