Gynecologic and Obstetric Pathology

Dysgerminoma

D efinition — A malignant, primitive germ cell tumor of the ovary that is the counterpart to testicular seminoma. Clinical Features Epidemiology Rare; represents only 1% of all ovarian germ cell tumors but is the most common malignant germ cell…

Malignancy Arising in Teratomas

D efinition — A malignant tumor of somatic tissues arising from an element of mature teratoma. Clinical Features Epidemiology Rare, occurring in 1% of mature cystic teratomas. Approximately 90% are epithelial, 80% of which are squamous carcinomas. Mean age is…

Metastatic Carcinoid

D efinition — Metastatic carcinoid, usually from the gastrointestinal tract. Clinical Features Epidemiology The majority of metastatic carcinoids are of distal ileal origin. Have a wide age range, but most will be postmenopausal. You’re Reading a Preview Become a Clinical…

Strumal Carcinoid

D efinition — A monodermal teratoma composed of both struma (thyroid) and a trabecular carcinoid. Clinical Features Epidemiology Strumal carcinoids are rare tumors with bidirectional differentiation, resulting in both thyroid and neuroendocrine differentiation. Seen over a wide age range, from…

Malignant Struma

D efinition — Malignant teratomatous thyroid tissue (carcinoma). Clinical Features Epidemiology Association with mature cystic teratomas and struma ovarii. Mean age is approximately 43 years. Approximately 5% of struma are malignant, at least focally. Some estimates are higher and this…

Struma Ovarii

D efinition — A teratoma composed principally of thyroid tissue. Clinical Features Epidemiology Struma ovarii is a monodermal ovarian teratoma predominantly composed of thyroid tissue. Seen most commonly in the fifth decade of life. Virtually always unilateral. Contralateral cystic teratoma…

Fetiform Teratoma

D efinition — A teratoma recapitulating human form. Clinical Features Epidemiology Exceedingly rare, reproductive-age group. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in…

Mature Cystic Teratoma: Normal Neural Differentiation

D efinition — Germinal matrix or cerebellar differentiation in a mature teratoma; mimics immature neuroepithelium. Clinical Features Epidemiology Occurs in typical benign cystic teratoma. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles…

Pseudomyxoma Peritonei

D efinition — A clinical term for increased mucin present within the abdominal cavity, typically associated with a low-grade mucinous tumor of the appendix or gastrointestinal tract. Clinical Features Epidemiology Pseudomyxoma is frequently associated with appendiceal neoplasms; however, occasional cases…

Metastatic Carcinoma to the Ovary

D efinition — Ovarian spread from remote nongynecologic epithelial neoplasms. Clinical Features Epidemiology Sixty to eighty percent of metastatic tumors are nonmüllerian, including stomach (6% to 14%); colon (7% to 12%); breast (9% to 32%); and rarely lung, biliary duct,…