Gynecologic and Obstetric Pathology

Juvenile Granulosa Cell Tumor

PITFALL D efinition — A sex cord–stromal tumor seen in the first decades of life that closely resembles the developing follicle. Clinical Features Epidemiology Granulosa cell tumors (GCTs) comprise less than 2% of ovarian tumors. Juvenile GCTs comprise less than…

Granulosa Cell Tumor Variants

PITFALL D efinition — Diagnostically challenging variant patterns include those with nuclear atypia, cystic architecture, thecoma-like, luteinized, and sertoliform. Clinical Features Epidemiology Uncommon. The granulosa cell tumor (GCT) comprises less than 2% of ovarian tumors. Over 90% will be adult…

Granulosa Cell Tumor

D efinition — An ovarian steroid-producing sex cord–stromal tumor composed of cells resembling the granulosa cells of the developing follicle. Clinical Features Epidemiology Uncommon. Perimenopausal or postmenopausal women. Mean age at presentation is in the mid-50s. You’re Reading a Preview…

Sclerosing Peritonitis

D efinition — A rare, potentially fatal process of thickening of the peritoneum/mesentery that has been rarely associated with luteinized thecomas. Clinical Features Epidemiology Sclerosing peritonitis is an uncommon entity that occurs most commonly in the seventh decade of life.…

Fibroma with Minor Sex Cord Elements

D efinition —A benign ovarian fibroma with nests or cords of sex cord elements. Clinical Features Epidemiology Rare. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a…

Thecoma-Fibroma

D efinition — A benign ovarian stromal tumor composed of cells resembling ovarian stroma with variable theca cell differentiation. Clinical Features Epidemiology Fibromas are common, typically solitary, and found most commonly after menopause. Pure thecomas are rare and account for…

Mixed Germ Cell Tumor

D efinition — A malignant germ cell tumor of the ovary with two or more germ cell elements. Clinical Features Epidemiology Rare; represents less than 5% of all ovarian germ cell tumors. Most cases arise in patients in their teens…

Immature Teratoma

D efinition — A malignant germ cell tumor recapitulating fetal somatic differentiation. Clinical Features Epidemiology Rare, comprising less than 1% of all germ cell tumors but third most common malignant germ cell tumor in young women. Mean age of 19…

Embryonal Carcinoma

D efinition — A malignant, primitive germ cell tumor of the ovary with embryonic differentiation. Clinical Features Epidemiology Rare; represents less than 5% of all malignant ovarian germ cell tumors. Most cases arise in patients in their teens or twenties…

Yolk Sac Tumor

D efinition —A malignant germ cell tumor with endodermal sinus or vitelline differentiation. Clinical Features Epidemiology The majority of patients are in their teens or twenties, although cases commonly occur in the first and fourth decades of life as well.…