Gynecologic and Obstetric Pathology

Pseudobowenoid Papulosis

PITFALL D efinition —An unusual variant of condyloma that is marked by a striking increase in apoptosis in the upper epithelial layers. Clinical Features Epidemiology Occurs in the same demographic groups as typical condyloma; however, disease is secondary to more…

Seborrheic Keratosis

D efinition —A benign, warty proliferation of keratinocytes that is frequently pigmented and often associated with low-risk human papillomavirus (HPV) (types 6 and 11). Clinical Features Epidemiology Can be seen in all age groups. A large percentage are associated with…

Fibroepithelial Stromal Polyp

D efinition —Benign polypoid vulvovaginal lesions of young- to middle-aged women with a striking array of histologic appearances, often associated with pregnancy. Clinical Features Epidemiology Young- to middle-aged women. Multiple lesions are associated with pregnancy. Very rare before menarche. You’re…

Warty Dyskeratoma

D efinition —A solitary acanthotic and dyskeratotic epidermal proliferation. Clinical Features Epidemiology Rare disease, most often seen in the head and neck regions. Very rarely involves the vulva. Not an inherited condition (as opposed to Darier's disease). You’re Reading a…

Verruciform Xanthoma

D efinition —Verruciform xanthoma is a solitary benign verrucous lesion of the vulva that contains foamy histiocytes in the lamina propria. Clinical Features Middle-aged women. Solitary wartlike growth on the genital area. No relationship to human papillomavirus (HPV). You’re Reading…

Condyloma

D efinition —Benign squamous tumors caused by infection of human papillomavirus (HPV). In this chapter condyloma includes two verruciform variants: classic condyloma and fibroepithelial papilloma. A third, seborrheic, keratosis-like condyloma will be discussed separately. Clinical Features Epidemiology Very common sexually…

Bartholin’s Gland Carcinoma

D efinition —A malignancy arising in the Bartholin's glands or ducts. Clinical Features Epidemiology Very rare. Incidence of approximately one per million. Approximately 75% are squamous carcinomas, and the remainder include adenoid cystic carcinoma; adenocarcinoma, not otherwise specified (NOS); epithelial–myoepithelial…

Adenoid Cystic Carcinoma

D efinition —A slow-growing/indolent malignancy derived from the Bartholin's gland with a tendency for late metastasis. Clinical Features Epidemiology Very rare. Accounts for less than 1% of vulvar malignancies. Wide age range, with an average age in the fourth decade.…

Bartholin’s Adenoma

D efinition —An increase in the number of Bartholin's glands with a generalized loss of architecture. Clinical Features Epidemiology Occurs across a wide age range; however, adenomas generally occur at an older age. Very rare. You’re Reading a Preview Become…

Hyperplasia of Bartholin’s Gland

D efinition —An increase in the number of Bartholin's glands with preservation of normal architecture. Clinical Features Epidemiology Seen in a wide age range. Hyperplasia of Bartholin's glands generally occurs at a younger age than adenoma. You’re Reading a Preview…