Gynecologic and Obstetric Pathology

Melanoma

PITFALL D efinition —A very aggressive malignant tumor of dermal melanocytes arising in the vagina. Clinical Features Epidemiology Uncommon but not rare. Typically seen in postmenopausal women. May be more common in patients with a BRCA2 mutation. You’re Reading a…

Metastatic Adenocarcinoma

D efinition —Epithelial malignancies that metastasize to the vagina. Clinical Features Epidemiology Patients with a primary carcinoma of another site. The vast majority are of endometrial origin. Over 90% of adenocarcinomas identified in the vagina are metastatic. You’re Reading a…

Clear-Cell Adenocarcinoma

D efinition —An uncommon primary adenocarcinoma of the vagina, associated with in utero exposure to synthetic estrogen. Clinical Features Epidemiology Rare, except in women who were exposed to diethylstilbestrol (DES) in utero. The risk in DES-exposed women is estimated to…

Papillary Squamous Carcinoma

D efinition —A malignant neoplasm of the vagina comprised of squamous epithelial cells with prominent papillary architecture. Clinical Features Epidemiology Associated with high-risk human papillomavirus (HPV) infection and may follow preexisting cervical intraepithelial or invasive neoplasia. Usually older women, in…

Radiation-Induced Atrophy

D efinition —Iatrogenically induced atrophic changes seen in the vaginal mucosa following radiation therapy. Clinical Features Epidemiology Common occurrence following radiation therapy. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership…

High-Grade Vaginal Intraepithelial Neoplasia III

D efinition —Human papillomavirus (HPV)–related proliferation of the vaginal mucosa that leads to extensive, full-thickness loss of maturation of the vaginal epithelium. Clinical Features Epidemiology Patients present at a slightly older age than those with cervical dysplasia, with the majority…

Vaginal Papillomatosis (Residual Hymenal Ring)

PITFALL D efinition —Villiform remnants of hymenal ring. Clinical Features Epidemiology Typically seen in young women of reproductive age. No symptoms. Not related to human papillomavirus (HPV). You’re Reading a Preview Become a Clinical Tree membership for Full access and…

Polypoid Endometriosis

D efinition —A mass-forming, proliferative focus of misplaced endometrial glands and stroma within the vagina. Clinical Features Epidemiology Uncommon; vaginal endometriosis accounts for less than 10% of all endometriosis, with the most common form being traditional endometriosis composed of glands…