D efinition — Ectopic endometrial glands and stroma (endometriosis) or endometrial stroma in isolation (stromatosis). Clinical Features Epidemiology Endometriosis is common. Seen across all ages and demographic groups. Often follows punch or cone biopsy presumably because endometrial tissue colonizes the…
D efinition — A distinct subset of adenocarcinoma in situ (AIS) with intestinal differentiation. Clinical Features Epidemiology Average age at diagnosis is 45 years (about 10 years older than conventional AIS). Human papillomavirus (HPV) detected in approximately 66%. You’re Reading…
D efinition — A stratified mucin-producing intraepithelial lesion with prominent columnar cell differentiation (also called stratified adenocarcinoma in situ [AIS]). Clinical Features Epidemiology Young women, most ranging in age from 20 to 40 years. High-risk human papillomavirus (HPV) associated. You’re…
D efinition — Precursor lesion to invasive endocervical adenocarcinoma. Clinical Features Epidemiology Average age at diagnosis is 38 years. Human papillomavirus (HPV) related (>90%), especially types 16 and 18 in roughly equal proportion. About half of cases have a concurrent…
D efinition — A subtle pattern of endocervical adenocarcinoma in situ (AIS) which is frequently mistaken for reactive epithelial change. Clinical Features Epidemiology Young women; mean age at diagnosis is early 20s. Human papillomavirus (HPV) associated. You’re Reading a Preview…
D efinition — A poorly differentiated nonkeratinizing squamous carcinoma with prominent lymphocytic infiltrates. Clinical Features Epidemiology A malignant cervical neoplasm. Most prevalent in the fourth to sixth decades of life. Human papillomavirus (HPV) testing of a few cases has been…
D efinition —A specific pattern of invasive carcinoma that either mimics crypt involvement or combines crypt involvement with invasion, thus mimicking noninvasive carcinoma. Clinical Features Epidemiology The same as conventional invasive squamous carcinoma. You’re Reading a Preview Become a Clinical…
D efinition —A malignant neoplasm of the cervix comprised of squamous epithelial cells. Variants include large-cell keratinizing, large-cell nonkeratinizing, and small-cell nonkeratinizing squamous cell carcinoma (SCC), as well as papillary SCC. Clinical Features Epidemiology Associated with high-risk human papillomavirus (HPV)…
D efinition —Early invasive squamous cell carcinoma (SCC) measuring no more than 3 mm in depth in the biopsy or conization specimen. Clinical Features Epidemiology Associated with high-risk human papillomavirus (HPV) infection and preexisting cervical intraepithelial neoplasia. Will be found in…
D efinition —A squamous intraepithelial lesion not amenable to precise grading (QSIL) that demonstrates features seen in both low-grade squamous intraepithelial lesion (LSIL) and high-grade squamous intraepithelial lesion (HSIL). Clinical Features Epidemiology Typically encountered in reproductive-age women with atypical squamous…