Key Points Incidence In the United States, approximately 228,150 cases of lung cancer and approximately 142,670 deaths were projected from lung cancer in 2019. Incidence is decreasing in the United States while increasing worldwide, reflecting patterns in tobacco use. Routine…
Key Points Incidence Small cell lung cancer (SCLC) represents about 15% of over 230,000 annual lung cancer diagnoses in the United States. Only about one-third present without metastatic disease. Biological Characteristics SCLC is a high-grade tumor of the lung, with…
Primary thoracic neoplasms are reviewed in detail in the chapters of this section. In this overview, we consider developments and controversies in the diagnosis and treatment of non–small cell lung cancer (NSCLC), small cell lung cancer (SCLC), thymic tumors, pulmonary…
Key Points Incidence It was estimated that in 2018 there would be 91,270 new cases of melanoma diagnosed and 9320 deaths in the United States. Biological Characteristics Sun exposure is clearly associated with the development of cutaneous melanoma. Inherited mutations…
Key Points Incidence Cutaneous basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs) are the most frequent cancers worldwide. Caucasian populations residing in locations with high level exposure to ultraviolet (UV) radiation, such as Australia and New Zealand and the…
Assessment and treatment of regional lymph nodes in the neck are of utmost importance in the treatment of patients with head and neck squamous cell carcinoma (HNSCC). The philosophy of treatment of the neck has evolved over the past several…
Key Points Incidence Carcinoma of an unknown primary tumor (CUP) in the head and neck describes a patient with cervical node metastases without a physically or radiologically identifiable primary tumor site. Approximately 3% of patients with head and neck squamous…
Key Points Incidence Thyroid cancer incidence in the United States increased on average 3.6% per year during 1974 to 2013 (from 4.56 per 100,000 person-years in 1974 to 1977 to 14.42 per 100,000 person-years in 2010 to 2013) mainly owing…
Key Points Incidence The overall incidence of salivary gland malignancies in the general population is about 0.9 to 4.0 new cases per 100,000 population per year. Biologic Characteristics Prognostic factors relate to histology, grade, primary tumor size and extent, lymph…
Key Points Incidence and Epidemiology Sinonasal cancers comprise less than 1% of all malignant neoplasms and the American Cancer Society estimates 2000 Americans develop cancers of the nasal cavity and paranasal sinuses annually. Men are 50% more likely to be…