Fanaroff and Martin's Neonatal-Perinatal Medicine

Congenital Anomalies

Major anomalies are seen in about 2% of newborns, often prompting parental worry and urgent medical intervention soon after birth. In addition, they are a common cause of long-term illness and death. This chapter reviews some of the significant etiologic…

Birth Injuries

Birth injuries are those sustained during the birth process, which includes labor and delivery. They may be avoidable, or they may be unavoidable and occur despite skilled and competent obstetric care, as in an especially hard or prolonged labor or…

Placental Pathology

The placenta has two opposing functions. It is the sole source of sustenance for the fetus and its sole protection against noxious external influences. It can be argued that no evaluation of a sick neonate is complete without knowing the…

Perinatal Infections and Chorioamnionitis

Definitions and Epidemiology Chorioamnionitis (or intra-amniotic infection) is a major cause of fetal, neonatal, and maternal morbidity and mortality. There are strong associations between chorioamnionitis and maternal morbidity, preterm birth, early-onset neonatal sepsis, bronchopulmonary dysplasia, retinopathy of prematurity, and diffuse…

Amniotic Fluid Volume

Amniotic fluid surrounds the developing embryo throughout gestation, protecting the fetus and umbilical cord from trauma while allowing mobility to facilitate structural growth and development. The underlying forces that regulate amniotic fluid are exceedingly complex and dynamic, synchronizing volumes within…