Critical Care Nephrology

Anticoagulation Strategies for Continuous Renal Replacement Therapy

Objectives This chapter will: 1. Describe nonanticoagulant measures to promote circuit patency. 2. Identify the ideal anticoagulant for continuous renal replacement therapy. 3. Describe the advantages and risks of the most commonly used anticoagulant strategies. 4. Provide basic recommendations for…

Vascular Access for Acute Renal Replacement Therapy

Objectives This chapter will: 1. Review central venous catheter as the vascular access standard reference for renal replacement therapy in acute kidney failure (stage 3 acute kidney injury). 2. Describe the two main categories of central venous catheters: short-term or…

Solute and Water Kinetics in Continuous Therapies

Objectives This chapter will: 1. Describe the basic mechanisms of fluid transport and solute removal (ultrafiltration, diffusion, convection, and adsorption) and the factors influencing these processes in continuous renal replacement therapy. 2. Describe the manner in which the basic principles…

Cascade Filtration for ABO Incompatible Transplant

Objectives This chapter will: 1. Briefly describe desensitization protocols used in ABO incompatible renal transplantation. 2. Describe the extracorporeal technique used to remove circulating antibodies against A and B antigens. 3. Describe the characteristics of cascade filtration. Barrier of ABO…

The Role of Plasmapheresis in Critical Illness

Objectives This chapter will: 1. Review the techniques of plasmapheresis. 2. Review the indications and evidence for plasmapheresis and therapeutic plasma exchange in critical illness. Extracorporeal blood purification by plasmapheresis has been more streamlined and gained more interest by intensivists…

Hybrid Dialysis Techniques in the Intensive Care Unit

Objectives This chapter will: 1. Define and give the rationale for hybrid renal replacement therapy. 2. Discuss the technical requirements of hybrid renal replacement therapy. 3. Explain the versatility and flexibility of hybrid renal replacement therapy prescription and provision. 4.…