Introduction Antibiotics alone, or in combination with other therapeutic strategies, have been empirically used in hidradenitis suppurativa (HS) with variable success, resulting only in temporary symptom relief in the disease process. Although very few randomized controlled studies have been performed…
Introduction Topical therapy is a mainstay of dermatological treatment and holds many advantages, including ease of use, relative lack of systemic side effects, and patient-directed application. In hidradenitis suppurativa (HS), topical therapeutics are often used for early-stage lesions or as…
Introduction Long considered an orphan disease until recent years, hidradenitis suppurativa (HS) is rapidly gaining attention in the healthcare field with a growing spotlight on investigating HS pathogenesis, epidemiology, and treatment options. To better navigate the expanding therapeutic options available,…
Introduction Outcome measures play an important role in the field of dermatology, both in routine clinical practice and in clinical research trials. In clinical settings, robust outcome measures serve to classify disease severity, which can direct treatment choice. Outcome measures…
Introduction Hidradenitis suppurativa (HS) is an inflammatory condition characterized by painful and sometimes purulent nodules, abscesses, and sinus tracts located in intertriginous regions. Lesions may progress to form hypertrophic scars or dermal tunnels. HS patients are regarded as having one…
Introduction Hidradenitis suppurativa (HS) is a disabling chronic inflammatory disease with significant comorbidities that affects an estimated 1% of the Western population. A poor understanding of HS biology has limited the development of uniformly effective treatments. The characteristic lesions of…
Introduction The pathogenic model of hidradenitis suppurativa (HS) may be in the midst of a paradigm shift, balancing the initial model of a disorder of (primary) follicular occlusion with consideration as an autoinflammatory keratinization disease (AiKD). There is observational, experimental,…
Introduction Over time, repeated episodes of hidradenitis suppurativa (HS) disease flares can lead to a number of debilitating cutaneous, systemic, as well as psychological and social complications. Given the progressive course of this disease, early diagnosis and initiation of appropriate…
Introduction HS represents a prime candidate to bridge diseases of the integument and comorbid systemic disease, as a chronic inflammatory disease of the pilosebaceous unit characterized by inflammatory nodules, suppuration and abscess formation resulting in pain and disfigurement. In addition…
Overview of Patient Population with HS Prior to Initiating Therapy Hidradenitis suppurativa is a clinical diagnosis based on history, physical exams, patterns of recurrence, types of lesions, and scarring. No diagnostic test is currently available and biopsy results are relatively…