Editors' comment: We welcome the addition of a new coauthor to this chapter, Alisse Hauspurg MD, who brings expertise in Maternal Fetal Medicine with a focus on hypertensive disorders of pregnancy. The chapter has been revised and updated to include…
Editors' comment : It was not until the early 1980s that physicians and scientists gained an appreciation of the physiological importance of the endothelium, the simple unicellular layer lining the luminal surface of blood vessels. Indeed, in Chesley's first, single-authored…
Editors' comment: When Chesley wrote his original monograph, he, like most of the scientific community, was unfamiliar with the concept of angiogenesis. Even in the multiauthored second edition, in which the endothelial cell hypothesis of preeclampsia was first proposed, the…
Acknowledgments MV is grateful to Drs. William Cooke, Sofia Cerdeira, and Neva Kandzija for their helpful contributions to this chapter. CR acknowledges the major contributions from Ian Sargent, who developed the STBEV story in Oxford. Editors' comment: This is a…
Editors' comment : In Chesley's single-authored first edition, there was limited information regarding immunology and preeclampsia. He did note that as early as 1902, Viet had proposed that deported trophoblastic fragments were antigenic and could elicit antibodies that he named…
Editors' comment: This is a modified chapter since the fourth edition. When it was published in 2015, the editors had come to the realization that methods revealing the molecular biology of the trophoblast were likely to contribute in new ways…
Acknowledgments The authors gratefully acknowledge the input of their clinical and research colleagues over the years that have helped shape their views and to funders including The Wellcome Trust, Medical Research Council, Tommy's and Wellbeing of Women, who have supported…
Editors' comment: Chapter 4 titled “Pre- and Peri-Conception Pathways to Preeclampsia” is a new addition to Chesley's Hypertensive Disorders in Pregnancy. The rationale for this chapter stems from the emerging evidence supporting the concept that the antecedents of preeclampsia may…
Editors' comment : Case reports describing familial clustering of eclampsia were first reported in the late 1800s, but Chesley was one of the first to perform a true genetic analysis. Chesley's first edition text summarized his early investigations in hundreds…
Editor's comment: Preeclampsia–eclampsia is a leading cause of maternal mortality and morbidity. Eclampsia has decreased dramatically in the last several decades in high-resource countries, probably reflecting improvements in medical care rather than a change in the disease's natural history. Conversely,…