Introduction Small cell lung carcinoma (SCLC) is a highly aggressive tumor, with a high proliferative capability, rapid tumor doubling time, and early onset of metastases carrying a poor prognosis. These features make SCLC a systemic disease in most cases, with…
Introduction Brain metastases from lung cancer represent a significant portion of all brain metastases. Between 10% and 25% of patients with lung cancer have brain metastases at diagnosis, and about 40–50% of all patients with lung cancer will develop brain…
Introduction Small cell lung cancer (SCLC) is the most aggressive histologic subtype of lung cancer, with a strong predilection for metastasizing early. About 10% of patients with SCLC develop brain metastasis at the time of diagnosis, and the majority of…
Introduction Small cell lung cancer (SCLC) accounts for about 15–20% of all lung cancers. It is both chemo- and radiosensitive. The brain is a common site of metastases. Unfortunately, because of the blood–brain barrier, chemotherapy may not be able to…
Introduction Lung cancer is the leading cause of cancer-related mortality worldwide ( ). The majority of patients with NSCLC present with locally advanced or metastatic disease. The development of brain metastases is a common site of recurrence and spread (…
Introduction Lung cancer affects approximately 1.6 million persons a year globally. In the West, it accounts for approximately 10–15% of new cancer cases and 20–30% of cancer deaths ( ). Metastasis to the brain is responsible for death in up…
Introduction Brain metastases affect 25% of patients with systemic cancer and are at least four times more common than primary brain tumors ( ). Nearly half of brain metastases arise from the lung and involve the cerebral hemispheres 80% of…
Introduction A 60-year old never-smoker woman presents with left-sided weakness and ataxia due to innumerable metastatic lesions within the brain originating from an advanced adenocarcinoma of the lung. She receives whole brain radiotherapy (WBRT) and systemic chemotherapy and her symptoms…
Introduction Stage IV metastatic disease will be found in approximately 30–40% of patients with non-small cell lung cancer (NSCLC). The brain represents the most common metastatic site for primary lung. The presence of a solitary brain metastasis is a common…
Introduction Lung cancer leads the ranking of cancer-related mortality in both the USA and Europe ( ). Non-small cell lung cancer (NSCLC) shows predominance over small cell histology (SCLC), which accounts for only 15–20% of the incident cases ( ).…