Part 1

Unlike in the cervix and vagina, cytology plays little role in the diagnosis of vulvar disease. Because the vulva is clearly visible and easily magnified with the aid of a colposcope, suspicious changes are easily observed as areas that are different from the surrounding normal skin. The diagnosis of vulvar disorders is always confirmed by biopsy.

Embryonic

Fig. 63.1 shows a rather common finding of a softish papillary lesion located lateral to the lower labium majus. Excisional biopsy reveals this to be a remnant of the embryonic milk line. Fig. 63.2 is an excellent illustration of Hart’s line on the inner surface of the labium minus.

FIG. 63.1, A. Pigmented papillary tissue may be seen on the skin between the thigh and the vulva. This is a remnant of the embryonic milk line. B. Biopsy of the structure shows it is an accessory nipple. This tissue contains apocrine glands and ducts that are seen in the mammary gland tissue normally located on the ventral wall of the chest.

FIG. 63.2, A sharp, irregular line is seen on the medial aspect of the labium minus. This dentate-shaped landmark, named Hart’s line, forms the boundary between the labium minus and vestibule.

Infections

Parasitic Infections

Vulvar infection with the crab louse is contracted through intimate contact with infected genitalia. The symptoms are intense itching in the hair-bearing areas. The colposcope permits scanning and localization of eggs or moving lice ( Fig. 63.3 ).

FIG. 63.3, A small, moving white speck was seen in the pubic hair. A magnified view showed a crab louse.

Bacterial Infections

Several organisms cause acute vulvitis. Diffuse erythema may be associated with vascular ectasia in the form of fine punctation ( Fig. 63.4A and B ). This pattern is characteristic of infection with enteric organisms, such as enterococcus, Escherichia coli, mycoplasma, and Ureaplasma species. Another pattern is large, punched-out shallow ulcers that may be seen with mixed gram-positive organisms, such as streptococcus and staphylococcus (see Fig. 63.4C and D ). Colposcopy shows heaped-up white epithelium at the periphery of the ulcers. The lesions, as a group, cause pain, itching, and a sense of dryness and swelling (see Fig. 63.4E ).

FIG. 63.4, A. These striking red inflammatory skin changes diffusely affect the entire vulva, typifying acute vulvitis. B. These deep wine-red skin changes involve the labia minora, labia majora, and vestibule and are associated with contact vulvitis. These lesions caused itching that progressed to burning. C. These large, sharp, bright red ulcers cause intense vulvar itching. Culture showed a predominantly staphylococcal infection. The differential diagnosis included pemphigus. D. The patient seen in C , 1 week after the initiation of treatment. E. The patient seen in C and D , 2 weeks after the initiation of treatment. Healing is apparent; the redness is diminished, and the ulcers have filled in.

Fungal Infections

Fungal vulvitis causes massive, diffuse erythema; scaling associated with chronicity; and folliculitis ( Fig. 63.5A to C ). With acute fungal or bacterial infection, a fiery, red vulva may be seen (see Fig. 63.5D ). Fungal vulvitis begins with pruritus and progresses to burning pain. Scaling suggests long-standing fungal infection (see Fig. 63.5E and F ).

FIG. 63.5, A . The vulvar vestibule and the medial aspects of the labia minora are red. A profuse white discharge covers the introitus, hymenal ring, and urethral meatus. B . The labium majus is inflamed. Redness is seen around the hair follicles. Folliculitis may be seen with fungal or bacterial vulvitis. C. Folliculitis and scaling associated with erythema are characteristic of chronic fungal infection. D. Acute fungal vulvitis causes pruritus followed by burning discomfort. E. Lesions that show fissures and scaling should be scraped onto fungal culture medium to establish the diagnosis. F. Vulvar biopsy can be used to diagnose fungal vulvitis. Periodic acid–Schiff stain shows mycelia in the stratum corneum.

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