Key Concepts

  • Acute pelvic pain in women is often from a gynecologic source, but urinary and intra-abdominal sources are also common. Less frequently, the pain may arise from vascular, musculoskeletal, neurologic, or psychiatric disorders.

  • Potentially lethal diagnoses associated with acute pelvic pain include ectopic pregnancy, ovarian cyst with significant hemorrhage, and domestic violence; highly morbid conditions presenting with acute pelvic pain include pelvic inflammatory disease and ovarian torsion.

  • Nearly all women of childbearing age with pelvic pain should have a pregnancy test performed, and most should have a pelvic ultrasound examination.

  • Ectopic pregnancy should be excluded in the pregnant patient with pelvic pain. Bedside ultrasound is an excellent test for confirming an intrauterine pregnancy (IUP); it excludes ectopic pregnancy with a high degree of certainty in patients who are not using assisted reproductive technology.

  • Pregnant patients with acute pelvic pain may also have non–pregnancy-related disorders; appendicitis, nephrolithiasis, and ovarian torsion, among others, remain in the differential diagnosis.

  • Many patients with acute pelvic pain require imaging as part of their assessment. If a gynecologic source is suspected, begin with an ultrasound and then progress to computed tomography (CT) or magnetic resonance imaging (MRI), if needed. The presence of an ovarian cyst on imaging does not necessarily explain the patient’s pain, and further evaluation may be required. Ultrasound after normal CT is unlikely to be informative. Ovarian torsion may be radiographically occult.

Foundations

Epidemiology

Acute pain caused by pelvic pathology is common, and the presenting complaint may be diffuse or lower abdominal pain, pelvic pain, or low back pain. A patient with chronic pelvic pain may also have an acute process related to the chronic condition or arising de novo.

More than one-third of reproductive age women will experience nonmenstrual pelvic pain. Among diagnoses for women with pain caused by gynecologic disorders in the emergency department (ED), pelvic inflammatory disease (PID) and lower genital tract infections (e.g., cervicitis, candidiasis, Bartholin abscess) account for almost 50%. Other common diagnoses are menstrual disorders, noninflammatory ovarian and tubal pathology (including cysts and torsion), and ectopic pregnancy. Ectopic pregnancy accounts for up to 20% of diagnoses among women presenting with vaginal bleeding or abdominal pain in the first trimester of pregnancy.

Younger patients and those with multiple sexual partners are more likely to have PID, and a previous episode increases the likelihood of a subsequent episode. The risk of ectopic pregnancy is higher in women who have had PID, pelvic surgery, prior ectopic pregnancy, or are using an intrauterine device (IUD). Heterotopic pregnancy is of special concern in women using assisted reproductive technology (ART). Although the rate of heterotopic pregnancy in spontaneous pregnancy is 1 in 30,000, this rate increases to as high as 1:1000 in patients undergoing ART. Common nongynecologic diseases such as appendicitis, diverticulitis, urinary tract infection, and urolithiasis remain important considerations in the woman with acute pelvic pain. Box 29.1 lists conditions accounting for most cases of pelvic pain in women.

BOX 29.1
Causes of Pelvic Pain in Women

Reproductive Tract

  • Ovarian torsion

  • Ovarian cyst

  • Pelvic inflammatory disease

  • Salpingitis

  • Tubo-ovarian abscess

  • Endometritis

  • Endometriosis

  • Uterine perforation

  • Uterine fibroids

  • DysmenorrheaVulvar/vaginal trauma

  • Neoplasm

Pregnancy Related

First Trimester

  • Ectopic pregnancy

  • Threatened abortion

  • Nonviable pregnancy

  • Ovarian hyperstimulation syndrome

Second and Third Trimesters

  • Placenta previa

  • Placental abruption

  • Round ligament pain

  • Labor or Braxton Hicks contractions

  • Uterine rupture

Intestinal Tract

  • Appendicitis

  • Diverticulitis

  • Ischemic bowel

  • Perforated viscus

  • Bowel obstruction

  • Incarcerated or strangulated hernia

  • Fecal impaction or constipation

  • Inflammatory bowel disease

  • Gastroenteritis/colitis

  • Irritable bowel syndrome

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