Key Concepts

  • Dyspnea results from a variety of conditions, ranging from nonurgent to life-threatening. Neither the clinical severity nor the patient’s perception correlates well with the seriousness of underlying pathology.

  • Dyspnea is subjective and the differential diagnosis can be divided into acute, acute on chronic, and chronic causes, of which the majority are cardiopulmonary. Other causes include metabolic, infectious, neuromuscular, traumatic, psychiatric, and hematologic conditions.

  • Chronic or progressive dyspnea usually denotes primary cardiac or pulmonary disease. Acute dyspneic spells may result from asthma exacerbation, infection, pulmonary embolism, cardiac dysfunction, or psychogenic causes.

  • All patients experiencing dyspnea, regardless of etiology, should be promptly evaluated. Bedside pulse oximetry readings should be obtained, and the patient placed on a cardiac monitor.

  • If the pulse oximetry is less than 92% on room air, the patient should be placed on supplemental oxygen either by nasal cannula or mask, depending on the degree of desaturation.

  • If altered level of consciousness, or hypoxia cannot be improved with suctioning, supplemental oxygen, or airway adjuncts then breathing should be assisted with manual or mechanical ventilation, either noninvasively for the short term, or with intubation for prolonged ventilation.

  • Unstable patients or patients with critical diagnoses must be stabilized and may require an emergent procedure and admission to an intensive care unit. Urgent patients who improve with emergency department management may be admitted to an intermediate care unit. Patients diagnosed with urgent conditions in danger of deterioration without proper treatment or patients with severe comorbidities, such as diabetes, immunosuppression, or cancer, may also require admission for observation and treatment.

Foundations

Dyspnea is the term applied to the uncomfortable sensation of breathlessness. It is described by patients in various ways, such as shortness of breath, chest tightness, or difficulty breathing. Dyspnea results from a variety of conditions, ranging from non-urgent to life-threatening. Neither the clinical severity nor the patient’s perception correlates well with the seriousness of underlying pathology and may be affected by emotions, behavioral and cultural influences, and external stimuli.

The following terms may be used in the assessment of the dyspneic patient:

  • Tachypnea: Greater than normal respiratory rate. Normal rates range from 44 cycles/min in a newborn to 14 to 18 cycles/min in adults.

  • Hyperventilation: A minute ventilation that exceeds metabolic demand.

  • Dyspnea on exertion: Dyspnea provoked by physical effort. It often is quantified simply as the number of stairs or number of blocks tolerated before symptom onset.

  • Orthopnea: Dyspnea in a recumbent position. It is commonly described as the number of pillows the patient uses to rest comfortably in bed (e.g., two-pillow orthopnea).

  • Paroxysmal nocturnal dyspnea: Sudden onset of dyspnea occurring while reclining at night.

Epidemiology

Dyspnea is a very common presenting complaint among emergency department (ED) patients of every age. Causes vary widely, and range from benign, self-limited conditions to life-threatening events. The symptom of dyspnea itself is an independent predictor of mortality. As chronic conditions become more prevalent, especially in the elderly, multiple etiologies may contribute to an individual’s symptoms. ,

Pathophysiology

Normal breathing is controlled both centrally by the respiratory control center in the medulla oblongata and peripherally by chemoreceptors located near the carotid bodies, but there are numerous sensory inputs that affect the feeling of dyspnea, including pulmonary stretch receptors and mechanoreceptors in the diaphragm and skeletal muscles. Imbalances among these inputs can be perceived as dyspnea and may manifest as increased work of breathing due to increased lung resistance, or decreased compliance in asthma or chronic obstructive pulmonary disease (COPD).

Diagnostic Approach

Differential Diagnosis Considerations

The differential diagnosis for dyspnea can be divided into acute, acute on chronic, and chronic causes. It spans a wide range of systems including cardiac, metabolic, infectious, neuromuscular, traumatic, hematologic, and psychiatric conditions ( Table 21.1 ).

TABLE 21.1
Differential Diagnoses for Acute Dyspnea
Organ System Critical Diagnoses Emergent Diagnoses Nonemergent Diagnoses
Pulmonary Airway obstruction Spontaneous pneumothorax Pleural effusion
Pulmonary embolus Asthma Neoplasm
Noncardiogenic pulmonary edema Cor pulmonale Pneumonia (CAP score ≤70)
Anaphylaxis Aspiration COPD
Ventilatory failure Pneumonia (CAP score >70)
Cardiac Pulmonary edema Pericarditis Congenital heart disease
Myocardial infarction Valvular heart disease
Cardiac tamponade Cardiomyopathy
PRIMARILY ASSOCIATED WITH NORMAL OR INCREASED RESPIRATORY EFFORT
Abdominal Mechanical interference Pregnancy
Hypotension, sepsis from ruptured viscus, bowel obstruction, inflammatory or infectious process Ascites, obesity
Psychogenic Hyperventilation syndrome
Somatization disorder
Panic attack
Metabolic or endocrine Toxic ingestion Renal failure Fever
DKA Electrolyte abnormalities Thyroid disease
Metabolic acidosis
Infectious Epiglottitis Pneumonia (CAP score >70) Pneumonia (CAP score ≤70)
Traumatic Tension pneumothorax Simple pneumothorax, hemothorax Rib fractures
Cardiac tamponade Diaphragmatic rupture
Flail chest Neurologic injury
Hematologic Carbon monoxide or cyanide poisoning Anemia
Acute chest syndrome
PRIMARILY ASSOCIATED WITH DECREASED RESPIRATORY EFFORT
Neuromuscular CVA, intracranial insult Multiple sclerosis ALS
Organophosphate poisoning Guillain-Barré syndrome Polymyositis
Tick paralysis Porphyria
ALS, Amyotrophic lateral sclerosis; CAP, community-acquired pneumonia; COPD, chronic obstructive pulmonary disease; CVA, cerebrovascular accident; DKA, diabetic ketoacidosis.

Pivotal Findings

You're Reading a Preview

Become a Clinical Tree membership for Full access and enjoy Unlimited articles

Become membership

If you are a member. Log in here