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Pain is a familiar phenomenon that is part of our everyday life and is a feature of various diseases. It most commonly accompanies an injury, where it serves its most important purpose, namely, to protect us, alert us and make us remove ourselves from danger. It can possibly trigger a spinal withdrawal reflex ( Fig. 11.1 ). Both congenital insensitivity to pain and extreme sensitivity to pain (paroxysmal extreme pain disorder and erythromelalgia) are rare genetic conditions, which are disabling and shorten life span, highlighting the importance of pain to our welfare and survival. Pain severity and its impact on an individual ranges from a trivial occurrence, such as a needle-prick injury, to a sensation of such intensity that it induces thoughts of suicide.
The International Association for the Study of Pain (IASP) proposed the following definition (1979): ‘Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage or described in terms of damage’. This definition has important implications. Pain is not necessarily or always associated with ongoing tissue damage; rather, it is a subjective experience and has an emotional as well as a sensory component and is always unpleasant.
Pain is notoriously difficult to describe and even harder to assess and quantify. Nevertheless, pain assessment is crucial in order to evaluate its impact on the sufferer and also to plan a treatment strategy. It has been termed ‘the 5th vital sign’ and is mandated as part of routine assessment of patients in hospital. In 2004 the IASP declared that the relief of pain should be a human right.
Although pain is a major source of suffering and economic burden for patients, until recently, it was not considered as a separate condition and systematically classified. Recognizing this, the World Health Organisation (WHO), in their recent adoption of the International Classification of Diseases (ICD-11) in May 2019, for the first time included chronic or long-standing pain as an independent disease and paved the way for a systematic classification of the condition.
There are many ways in which pain can be classified in order to formulate an optimal treatment strategy. Despite this, classifying a particular pain state can be challenging because the pain syndrome may be of mixed aetiology rather than fit into a single category.
Pain is commonly classified according to the following:
Aetiology and underlying condition
Mechanism
Duration
Trauma: an acute response to an injury
Surgery
Medical illness, such as myocardial infarction or appendicitis
Physiological conditions, such as menstruation and labour
Cancer
Inflammatory/Nociceptive: Pain generated and maintained by inflammatory mediators (such as prostaglandin E 2 ), secondary to an ongoing disease process. Examples include inflammatory arthritis.
Neuropathic: Neuropathic pain, which is generated in malfunctioning nerves, is defined as ‘pain arising as a direct consequence of a lesion or disease affecting the somatosensory system’. This type of pain has special clinical features as described below and may arise from injury or dysfunction of the central or peripheral nervous system. Examples include painful diabetic neuropathy and post-stroke pain.
Nociplastic: Nociplastic pain is a new terminology described in 2017. It is defined as pain that arises from altered nociception despite no clear evidence of actual or threatened tissue damage causing the activation of peripheral nociceptors or evidence for disease or lesion of the somatosensory system causing the pain. Examples include fibromyalgia, complex regional pain syndrome (CRPS) type 1, some ‘musculoskeletal’ pain conditions, such as ‘nonspecific’ chronic low back pain, and ‘functional’ visceral pain disorders, such as irritable bowel syndrome, bladder pain syndrome.
Mixed pain: This includes features of both nociceptive and neuropathic pain, such as back pain with radiculopathy (radiating leg pain caused by nerve irritation or compression).
Psychosomatic: Pure psychosomatic pain is rare. However, pain, especially chronic pain, almost invariably has an emotional and behavioural component.
Acute: Most commonly a physiological response to an injury. It resolves with the disappearance of a noxious stimulus or within the time frame of a normal healing process.
Chronic: It can either be associated with an ongoing pathological process, such as rheumatoid arthritis or degenerative disc disease, or be present for longer than is consistent with a normal healing time. Pain is arbitrarily described as chronic if it persists for longer than 3 months. Chronic pain is often associated with disability, mood and sleep disturbance and a significant behavioural response.
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