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Immune functions of osteoclasts: new insights for bone cancers


Research highlights

  • Osteoclasts are not only bone-resorbing cells. They are also monocytic cells with innate immune functions.

  • Osteoclasts participate in immune suppression to promote the development of bone cancer.

  • Osteoclasts display phenotypic and functional diversity and some osteoclast subsets are more prone to immune tolerance and immune suppression, making them interesting therapeutic targets in bone cancer.

Acknowledgments

The work was supported by the Agence Nationale de la Recherche (ANR-16-CE14-0030) as well as by the French government, managed by the ANR as part of the Investissement d’Avenir UCA JEDI project (ANR-15-IDEX-01). M-B. M. is supported by the Fondation pour la Recherche Médicale (FRM, ECO20160736019).

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