Alkylating Agents


Uses

  • Bone marrow transplants

  • Breast and bladder cancers

  • Lymphomas and leukemias

  • Cancers of the lung, pancreas, and brain

  • Ovarian and testicular cancers

  • Multiple myeloma

  • Sarcomas and melanomas

Perioperative Risks

  • Increased risk of infection

  • Aspiration (subsequent to N/V)

  • Prolonged succinylcholine action (CTX, thiotepa)

  • Fluid retention (HN 2 )

  • Prolonged bleeding (thrombocytopenia)

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