Cri Du Chat Syndrome (5p− Syndrome)

1:15,000-50,000 live births

Most common human chromosomal syndrome

Difficult airway management due to anatomic abnormalities of the airways.

30% can present with congenital heart disease.

Aspiration risk.

May require temp control.

Cardiac events (pts may have cardiac abnormalities).

Difficult mask ventilation; airway obstruction secondary to hypotonia

Difficult intubation

Temperature regulation

Microcephaly with profound mental retardation and hypotonia.

Characteristic facies with micrognathia, low-set ears, facial asymmetry.

Characteristic high-pitched cry may be due to laryngeal abnormalities (narrow diamond-shaped larynx, long floppy epiglottis) or neurogenic defect.

CHD: Persistent ductus arteriosus, septal defects, or pulmonic stenosis.

Behavioral features include repetition of movements, aggression, self-injury, and hypersensitivity to sound, among others.

Repetitive respiratory infections are common.