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The Risk Reducing Salpingo-Oophorectomy


D efinition — A procedure designed to remove the tubes and ovaries prior to the development of malignancy in women at high risk for ovarian cancer (BRCA1/2 germ-line mutations).

Clinical Features

Epidemiology

  • Heterozygous germ-line mutations in BRCA1 or BRCA2 occur in approximately 1 in 400 women in the general population and 1 in 40 women of Ashkenazi Jewish descent.

  • Lifetime risk of a pelvic fimbrial ovarian cancer is estimated at 40% and 10% for BRCA1 and BRCA2 mutation carriers respectively, without surgical intervention.

  • The vast majority of carcinomas are variants of high-grade serous carcinoma including “SET” (solid, endometrioid-like and transitional) patterns.

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