Lower Uterine Segment Adenocarcinoma

Epidemiology

• Uncommon variant of endometrial adenocarcinoma, accounting for from 3% to 6%.

• Associated with Lynch syndrome in up to 29% versus approximately 2% of conventional endometrial adenocarcinoma. A higher frequency of MSH2 loss has been reported by some.

• More commonly associated with higher-grade, deep myometrial invasion and less likely to have an associated endometrial intraepithelial neoplasia (atypical hyperplasia) or reproductive risk factors (such as parity and polycystic ovaries).