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D efinition —A unique, typically HPV-negative adenocarcinoma that has been associated with prenatal diethylstilbestrol exposure.
Rare.
Historically linked to diethylstilbestrol (DES) exposure in utero.
Sporadic occurrences now much more frequent than DES-related cases.
Wide age range, with a mean age of 45 to 50 years, but case reports include occurrences in children and adolescents.
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