Clear-Cell Carcinoma of the Cervix


D efinition —A unique, typically HPV-negative adenocarcinoma that has been associated with prenatal diethylstilbestrol exposure.

Clinical Features

Epidemiology

  • Rare.

  • Historically linked to diethylstilbestrol (DES) exposure in utero.

  • Sporadic occurrences now much more frequent than DES-related cases.

  • Wide age range, with a mean age of 45 to 50 years, but case reports include occurrences in children and adolescents.

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